Literature DB >> 51241

Integrator enzyme hypothesis for replication of hepatitis-B virus.

S Z Hirschman.   

Abstract

A hypothetical model for the replication of hepatitis-B virus is presented. It is suggested that the D.N.A. polymerase associated with Dane particles facilitates integration of viral D.N.A. into the genome of the liver cell. The viral D.N.A. is then replicated with the host genome. The hypothesis accounts for certain curious experimental and clinical observations and makes several predictions which are amenable to laboratory investigation.

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Year:  1975        PMID： 51241     DOI： 10.1016/s0140-6736(75)90847-8

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  7 in total

1.  Release of e antigen from a Dane particle-rich preparation of hepatitis B virus.

Authors:  K C Lam; M J Tong; J Rakela
Journal:  Infect Immun       Date:  1977-04       Impact factor: 3.441

2.  Relationship between HBV-specific DNA polymerase and HBe antigen/antibody system in chronic HBV infection: factors determining selection of patients and outcome of antiviral therapy.

Authors:  A Craxi; I V Weller; M F Bassendine; M J Fowler; J Monjardino; H C Thomas; S Sherlock
Journal:  Gut       Date:  1983-02       Impact factor: 23.059

Review 3.  The immunopathology of acute type B hepatitis.

Authors:  L Bianchi
Journal:  Springer Semin Immunopathol       Date:  1981-04

Review 4.  The hepatitis B virus and its DNA polymerase: the prototype three-D virus.

Authors:  S Z Hirschman
Journal:  Mol Cell Biochem       Date:  1979-07-15       Impact factor: 3.396

5.  Contribution of low level HBV replication to continuing inflammatory activity in patients with anti-HBe positive chronic hepatitis B virus infection.

Authors:  A S Lok; S J Hadziyannis; I V Weller; M G Karvountzis; J Monjardino; P Karayiannis; L Montano; H C Thomas
Journal:  Gut       Date:  1984-11       Impact factor: 23.059

6.  Chronic hepatitis in chimpanzee carriers of hepatitis B virus: morphologic, immunologic, and viral DNA studies.

Authors:  D Shouval; P R Chakraborty; N Ruiz-Opazo; S Baum; I Spigland; E Muchmore; M A Gerber; S N Thung; H Popper; D A Shafritz
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205

7.  State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

Authors:  C Bréchot; M Hadchouel; J Scotto; M Fonck; F Potet; G N Vyas; P Tiollais
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205
  7 in total

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