Literature DB >> 512207

Aberrant tonotopic organization in the inner ear damaged by kanamycin.

D Robertson, B M Johnstone.   

Abstract

Spiral ganglion cell recordings were obtained from normal and kanamycin-damaged guinea pig cochleas. Results show that kanamycin poisoning, which causes loss of outer hair cells, leads to a loss of sharp, sensitive tuning and, in addition, a shift to lower frequencies in the tuning curves from a damaged region. The normal tonoptic pattern of organization is therefore greatly disrupted in the damaged cochleas.

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Year:  1979        PMID： 512207     DOI： 10.1121/1.383097

Source DB:  PubMed          Journal:  J Acoust Soc Am        ISSN： 0001-4966            Impact factor:   1.840


  11 in total

1.  Centrifugal pathways protect hearing sensitivity at the cochlea in noisy environments that exacerbate the damage induced by loud sound.

Authors:  R Rajan
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

2.  The roles of the external, middle, and inner ears in determining the bandwidth of hearing.

Authors:  Mario A Ruggero; Andrei N Temchin
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-18       Impact factor: 11.205

Review 3.  Postnatal development of central auditory frequency maps.

Authors:  R Rübsamen
Journal:  J Comp Physiol A       Date:  1992-02       Impact factor: 1.836

Review 4.  Stem Cells and the Bird Cochlea-Where Is Everybody?

Authors:  Amanda S Janesick; Stefan Heller
Journal:  Cold Spring Harb Perspect Med       Date:  2019-04-01       Impact factor: 6.915

5.  Selective dysacusis--a preliminary report.

Authors:  A A Narula; S M Mason
Journal:  J R Soc Med       Date:  1988-06       Impact factor: 5.344

6.  Cochlear pharmacokinetics - Micro-computed tomography and learning-prediction modeling for transport parameter determination.

Authors:  Sanketh S Moudgalya; Kevin Wilson; Xiaoxia Zhu; Mikalai M Budzevich; Joseph P Walton; Nathan D Cahill; Robert D Frisina; David A Borkholder
Journal:  Hear Res       Date:  2019-06-01       Impact factor: 3.208

7.  Labile cochlear tuning in the mustached bat. II. Concomitant shifts in neural tuning.

Authors:  R F Huffman; O W Henson
Journal:  J Comp Physiol A       Date:  1993-01       Impact factor: 1.836

8.  Threshold tuning curves of chinchilla auditory-nerve fibers. I. Dependence on characteristic frequency and relation to the magnitudes of cochlear vibrations.

Authors:  Andrei N Temchin; Nola C Rich; Mario A Ruggero
Journal:  J Neurophysiol       Date:  2008-08-13       Impact factor: 2.714

9.  Efferent control of cochlear inner hair cell responses in the guinea-pig.

Authors:  M C Brown; A L Nuttall
Journal:  J Physiol       Date:  1984-09       Impact factor: 5.182

10.  Stimulus-related potassium changes in the organ of Corti of guinea-pig.

Authors:  B M Johnstone; R Patuzzi; J Syka; E Syková
Journal:  J Physiol       Date:  1989-01       Impact factor: 5.182
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