Literature DB >> 5120088

Unstirred water layers in intestine: rate determinant of fatty acid absorption from micellar solutions.

F A Wilson, V L Sallee, J M Dietschy.   

Abstract

Bile acid and fatty acid uptake from micellar solutions by intestinal cells fails to reflect the incremental free energy changes expected for permeation that is rate limited by cell membranes. However, altering the size of the diffulsing particle or the thickness of tle unstirred water layer does change uptake. These observations show that the unstirred water layer is rate limiting for intestinal absorption of lipids from micellar solutions.

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Year:  1971        PMID： 5120088     DOI： 10.1126/science.174.4013.1031

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

Review 1.  Spontaneous lipid transfer between organized lipid assemblies.

Authors:  R E Brown
Journal:  Biochim Biophys Acta       Date:  1992-12-11

2.  Impact of Hydrophilic Surfaces on Interfacial Water Dynamics Probed with NMR Spectroscopy.

Authors:  Hyok Yoo; Rajan Paranji; Gerald H Pollack
Journal:  J Phys Chem Lett       Date:  2011-02-18       Impact factor: 6.475

3.  Lymphatic and portal vein absorption of organochlorine compounds in rats.

Authors:  Ronald J Jandacek; Therese Rider; Qing Yang; Laura A Woollett; Patrick Tso
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2008-12-04       Impact factor: 4.052

Review 4.  New insights into the molecular mechanism of intestinal fatty acid absorption.

Authors:  Tony Y Wang; Min Liu; Piero Portincasa; David Q-H Wang
Journal:  Eur J Clin Invest       Date:  2013-09-18       Impact factor: 4.686

5.  Mechanism of intestinal fatty acid uptake in the rat: the role of an acidic microclimate.

Authors:  Y F Shiau
Journal:  J Physiol       Date:  1990-02       Impact factor: 5.182

6.  The intestinal uptake of phenol from micellar systems does not conform to the aqueous transfer model.

Authors:  P A Kothare; C L Zimmerman
Journal:  Pharm Res       Date:  2000-07       Impact factor: 4.200

7.  Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.

Authors:  Takuya Inoue; Joon-Ho Wang; Masaaki Higashiyama; Sergiy Rudenkyy; Kazuhide Higuchi; Paul H Guth; Eli Engel; Jonathan D Kaunitz; Yasutada Akiba
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2012-07-19       Impact factor: 4.052

8.  An exploration of the microrheological environment around the distal ileal villi and proximal colonic mucosa of the possum (Trichosurus vulpecula).

Authors:  Y F Lim; M A K Williams; R G Lentle; P W M Janssen; B W Mansel; S A J Keen; P Chambers
Journal:  J R Soc Interface       Date:  2013-02-06       Impact factor: 4.118

9.  Transport kinetics of D-glucose in human small intestinal mucosa: rate constants in histologically normal and abnormal mucosal biopsies.

Authors:  A B Thomson; W M Weinstein
Journal:  Dig Dis Sci       Date:  1979-06       Impact factor: 3.199

10.  Characterization of bile acid absorption across the unstirred water layer and brush border of the rat jejunum.

Authors:  F A Wilson; J M Dietschy
Journal:  J Clin Invest       Date:  1972-12       Impact factor: 14.808
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