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Literature DB >> 5117566

Incorporation of label from D- -hydroxy( 14 C)butyrate and (3- 14 C)acetoacetate into amino acids in rat brain in vivo.

Abstract

The metabolism of ketone bodies by rat brain was studied in vivo. Rats starved for 48h were given either d-beta-hydroxy[3-(14)C]butyrate or [3-(14)C]acetoacetate by intravenous injection and killed after 3 or 10min. Total radioactivity in the acid-soluble material of the brain and the specific radioactivities of the brain amino acids glutamate, glutamine, aspartate and gamma-aminobutyrate were determined. A group of fed animals were also given d-beta-hydroxy[3-(14)C]butyrate. In the brains of all animals (14)C was present in the acid-soluble material and the specific radioactivity of glutamate was greater than that of glutamine.

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Year: 1971 PMID： 5117566 PMCID： PMC1176756 DOI： 10.1042/bj1220135

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

18 in total

1. AMINO ACID METABOLISM IN RAT BRAIN STUDIED WITH 14C-LABELLED GLUCOSE.

Authors: J E CREMER
Journal: J Neurochem Date: 1964-03 Impact factor: 5.372

2. Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.

Authors: D H WILLIAMSON; J MELLANBY; H A KREBS
Journal: Biochem J Date: 1962-01 Impact factor: 3.857

3. Changes in D(--)-beta-hydroxybutyric dehydrogenase activity during brain maturation in the rat.

Authors: C B Klee; L Sokoloff
Journal: J Biol Chem Date: 1967-09-10 Impact factor: 5.157

4. Uptake of ketone bodies by rat brain in vivo.

Authors: R A Hawkins
Journal: Biochem J Date: 1971-01 Impact factor: 3.857

5. Metabolism of [14C]leucine and [14C]acetate in sensorimotor cortex, thalamus, caudate nucleus and cerebellum of the cat.

Authors: S Berl; T L Frigyesi
Journal: J Neurochem Date: 1968-09 Impact factor: 5.372

6. The effect of periodic convulsions induced by 1,1-dimethylhydrazine on the synthesis of rat brain metabolites from [2-14C]glucose.

Authors: F N Minard; I K Mushahwar
Journal: J Neurochem Date: 1966-01 Impact factor: 5.372

7. Precursors in vivo of glutamate, aspartate and their derivatives of rat brain.

Authors: R M O'Neal; R E Koeppe
Journal: J Neurochem Date: 1966-09 Impact factor: 5.372

8. Utilization in vivo of glucose and volatile fatty acids by sheep brain for the synthesis of acidic amino acids.

Authors: R M O'neal; R E Koeppe; E I Williams
Journal: Biochem J Date: 1966-12 Impact factor: 3.857

9. The fate of the alphah atom of L-lactate in perfused rat liver.

Authors: H D Hoberman
Journal: Ann N Y Acad Sci Date: 1965-07-31 Impact factor: 5.691

10. Selective inhibition of glucose oxidation by triethyltin in rat brain in vivo.

Authors: J E Cremer
Journal: Biochem J Date: 1970-08 Impact factor: 3.857

11 in total

1. β-Hydroxybutyrate Boosts Mitochondrial and Neuronal Metabolism but is not Preferred Over Glucose Under Activated Conditions.

Authors: Lavanya B Achanta; Benjamin D Rowlands; Donald S Thomas; Gary D Housley; Caroline D Rae
Journal: Neurochem Res Date: 2017-03-18 Impact factor: 3.996

2. Cortical substrate oxidation during hyperketonemia in the fasted anesthetized rat in vivo.

Authors: Lihong Jiang; Graeme F Mason; Douglas L Rothman; Robin A de Graaf; Kevin L Behar
Journal: J Cereb Blood Flow Metab Date: 2011-07-06 Impact factor: 6.200

Review 3. β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms.

Authors: Lavanya B Achanta; Caroline D Rae
Journal: Neurochem Res Date: 2016-11-08 Impact factor: 3.996

Review 4. Metabolic Alterations in Developing Brain After Injury: Knowns and Unknowns.

Authors: Mary C McKenna; Susanna Scafidi; Courtney L Robertson
Journal: Neurochem Res Date: 2015-07-07 Impact factor: 3.996

5. Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effect on mitochondrial biogenesis.

Authors: Dhaval P Bhatt; Heidi M Houdek; John A Watt; Thad A Rosenberger
Journal: Neurochem Int Date: 2013-01-12 Impact factor: 3.921

6. The estimation of rates of utilization of glucose and ketone bodies in the brain of the suckling rat using compartmental analysis of isotopic data.

Authors: J E Cremer; D F Heath
Journal: Biochem J Date: 1974-09 Impact factor: 3.857