Literature DB >> 511339

Quantitative correlation between the Dane particle-associated DNA polymerase and the hepatitis B e antigen.

W Siegert, J Grunst, W Wilmanns, G G Frösner, F Deinhardt.   

Abstract

In order to evaluate the potential infectivity of blood of hepatitis B patients, the Dane particle associated DNA polymerase was determined, which is a reliable marker for the presence of complete viral particles. Enzyme activities were compared with hepatitis B e antigen (HBeAg) titers determined by radioimmunoassay. Detectable DNA polymerase activity was only present in HBeAg positive blood, preferentially in samples with high antigen titers (1 : 1000 and above). These samples therefore have to be considered as highly infectious. However, blood with low HBeAg levels and free of detectable polymerase activity can still be infectious, since the polymerase reaction is rather insensitive compared to the radioimmunological HBeAg determination.

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Year:  1979        PMID: 511339     DOI: 10.1007/bf01648929

Source DB:  PubMed          Journal:  Infection        ISSN: 0300-8126            Impact factor:   3.553


  13 in total

1.  New specificities in Australia antigen positive sera distinct from the Le Bouvier determinants.

Authors:  L O Magnius; J A Espmark
Journal:  J Immunol       Date:  1972-11       Impact factor: 5.422

Review 2.  Hepatitis in primates.

Authors:  F Deinhardt
Journal:  Adv Virus Res       Date:  1976       Impact factor: 9.937

3.  Identification of additional antigenic sites on Dane particles and the tubular forms of hepatitis B surface antigen.

Authors:  A R Neurath; C Trepo; M Chen; A M Prince
Journal:  J Gen Virol       Date:  1976-03       Impact factor: 3.891

4.  Dane particles, DNA polymerase, and e-antigen in two different categories of hepatitis B antigen carriers.

Authors:  E Nordenfelt; L Kjellén
Journal:  Intervirology       Date:  1975       Impact factor: 1.763

5.  Type B hepatitis: the infectivity of blood positive for e antigen and DNA polymerase after accidental needlestick exposure.

Authors:  H J Alter; L B Seeff; P M Kaplan; V J McAuliffe; E C Wright; J L Gerin; R H Purcell; P V Holland; H J Zimmerman
Journal:  N Engl J Med       Date:  1976-10-21       Impact factor: 91.245

6.  Relation of e antigen to hepatitis B virus infection in an area of hyperendemicity.

Authors:  J E Maynard; D H Barrett; B L Murphy; D W Bradley; K R Berquist; T R Bender
Journal:  J Infect Dis       Date:  1976-03       Impact factor: 5.226

7.  Detection of HBeAg and anti-HBe in acute hepatitis B by a sensitive radioimmunoassay.

Authors:  G G Frösner; M Brodersen; G Papaevangelou; U Sugg; H Haas; I K Mushahwar; C M Ling; L R Overby; F Deinhardt
Journal:  J Med Virol       Date:  1978       Impact factor: 2.327

8.  DNA polymerase associated with human hepatitis B antigen.

Authors:  P M Kaplan; R L Greenman; J L Gerin; R H Purcell; W S Robinson
Journal:  J Virol       Date:  1973-11       Impact factor: 5.103

9.  Expression of hepatitis B virus-specific markers in asymptomatic hepatitis B surface antigen carriers.

Authors:  G H Arnold; J W Shih; P M Kaplan; R H Purcell; J L Gerin; K H Bueschenfelde
Journal:  Infect Immun       Date:  1977-09       Impact factor: 3.441

10.  Failure of antibody to e antigen to precipitate Dane particles containing DNA polymerase activity and hepatitis B core antigen.

Authors:  K Takahashi; S Yamashita; M Imai; Y Miyakawa; M Mayumi
Journal:  J Gen Virol       Date:  1978-03       Impact factor: 3.891

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  3 in total

1.  Chronic viral hepatitis B in childhood. II. Immunological studies in serum and liver tissue and family studies.

Authors:  C Bosch; M Becker; H W Rotthauwe; W Arnold; G Hess
Journal:  Eur J Pediatr       Date:  1981-03       Impact factor: 3.183

2.  Hepatitis B e-antigen titres for evaluating infectivity during hepatitis B virus infection.

Authors:  E G Lindenschmidt; C F Granato; C Salefsky; R Laufs; H Henning
Journal:  Klin Wochenschr       Date:  1984-03-01

3.  Immunoglobulin M antibodies to hepatitis B core antigen: evaluation of enzyme immunoassay for diagnosis of hepatitis B virus infection.

Authors:  M Roggendorf; F Deinhardt; G G Frösner; R Scheid; B Bayerl; R Zachoval
Journal:  J Clin Microbiol       Date:  1981-04       Impact factor: 5.948

  3 in total

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