Literature DB >> 5111567

Thyroxine: convesion to triiodothyronine by isolated perfused rat heart.

J L Rabinowitz, E S Hercker.   

Abstract

Thyroxine labeled with carbon-14 and iodine-125 was perfused through surviving rat hearts. Only when unlabeled triiodothyronine was added as a carrier could the newly formed doubly labeled triiodothyronine be isolated. The fact that this triiodothyronine was labeled with the correct ratio of carbon-14 to iodine-125 indicated that it originated from thyroxine. Approximately 5 percent of the initial carbon-14 radioactivity was found in the recovered triiodothyronine.

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Year:  1971        PMID： 5111567     DOI： 10.1126/science.173.4003.1242

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Subcellular localization of a rat liver enzyme converting thyroxine into tri-iodothyronine and possible involvement of essential thiol groups.

Authors:  T J Visser; I Does-Tobé; R Docter; G Hennemann
Journal:  Biochem J       Date:  1976-08-01       Impact factor: 3.857

2.  Conversion of thyroxine into tri-iodothyronine by rat liver homogenate.

Authors: 
Journal:  Biochem J       Date:  1975-09       Impact factor: 3.857

3.  Iodothyronine metabolism in rat liver homogenates.

Authors:  M M Kaplan; R D Utiger
Journal:  J Clin Invest       Date:  1978-02       Impact factor: 14.808

4.  Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis.

Authors:  S Nomura; C S Pittman; J B Chambers; M W Buck; T Shimizu
Journal:  J Clin Invest       Date:  1975-09       Impact factor: 14.808

5.  Studies of isolated fetal mouse hearts in organ culture. Evidence for a direct effect of triiodothyronine in enhancing cardiac responsiveness to norepinephrine.

Authors:  K Wildenthal
Journal:  J Clin Invest       Date:  1972-10       Impact factor: 14.808

6.  Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodothyronine.

Authors:  V S Lim; V S Fang; A I Katz; S Refetoff
Journal:  J Clin Invest       Date:  1977-09       Impact factor: 14.808

7.  The role of sulfhydryl groups on the impaired hepatic 3',3,5-triiodothyronine generation from thyroxine in the hypothyroid, starved, fetal, and neonatal rodent.

Authors:  A R Harris; S L Fang; L Hinerfeld; L E Braverman; A G Vagenakis
Journal:  J Clin Invest       Date:  1979-03       Impact factor: 14.808
  7 in total

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