Literature DB >> 511131

The genetic hypothesis for susceptibility to lepromatous leprosy.

D G Smith.   

Abstract

Evidence for genetic influence of the host response to infection with Mycobacterium leprae is reviewed. A complex segregation analysis is performed on data for 91 families from Mactan, Philippines, in each of which at least one offspring developed lepromatous leprosy. The data are not found to be inconsistent with an autosomal recessive hypothesis for susceptibility to lepromatous leprosy. Heritability estimates in the range of 80% were calculated for sib-sib pairs under the multifactorial hypothesis for susceptibility. It is argued that the multifactorial hypothesis is more in keeping with available immunologic, epidemiologic, and demographic data than is the single gene hypothesis.

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Year:  1979        PMID： 511131     DOI： 10.1007/bf00390238

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  51 in total

1.  THE DYNAMICS OF THE GC POLYMORPHISM IN A BRAZILIAN POPULATION.

Authors:  F M SALZANO; H HIRSCHFELD
Journal:  Acta Genet Stat Med       Date:  1965

2.  [Factor N of resistance to leprosy & relation of lepromin & tuberculin reactivity; doubtful value of BCG in immunization to leprosy].

Authors:  A ROTBERG
Journal:  Rev Bras Leprol       Date:  1957 Apr-Jun

3.  Serum cholinesterase variants in African leprosy patients resident in Rhodesia.

Authors:  M Whittaker; R F Lowe; B P Ellis
Journal:  Hum Hered       Date:  1976       Impact factor: 0.444

4.  ABO blood groups , Inv serum groups, and serum proteins in leprosy patients from West Bengal (India).

Authors:  F Vogel; J Kruger; M R Chakravartti; H Ritter; G Flatz
Journal:  Humangenetik       Date:  1971

5.  Levels of serum beta 1C-beta 1A globulin (C3) and its polymorphism in leprosy patients and healthy controls from Ethiopia and Mali.

Authors:  D P Agarwal; H G Benkmann; H W Goedde; R Rohde; H Delbrück; A Rougemont
Journal:  Humangenetik       Date:  1974-03-28

6.  The stigma of leprosy--in four countries.

Authors:  J C Pedley
Journal:  Lepr Rev       Date:  1972-06       Impact factor: 0.537

7.  Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India).

Authors:  H Walter; G Kellermann; M Bajatzadeh; J Krüger; M R Chakravartti
Journal:  Humangenetik       Date:  1972

8.  The genetics of resistance to leprosy.

Authors:  B Beiguelman
Journal:  Int J Lepr       Date:  1965 Oct-Dec

9.  Histocompatibility antigens (HL-A) in leprosy.

Authors:  A Dasgupta; N K Mehra; S K Ghei; M C Vaidya
Journal:  Tissue Antigens       Date:  1975-04

10.  Hereditary Characteristic that Varies Among Isolates of Mycobacterium leprae.

Authors:  C C Shepard; D H McRae
Journal:  Infect Immun       Date:  1971-01       Impact factor: 3.441
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  8 in total

Review 1.  Leprosy as a genetic disease.

Authors:  Andrea Alter; Audrey Grant; Laurent Abel; Alexandre Alcaïs; Erwin Schurr
Journal:  Mamm Genome       Date:  2010-10-09       Impact factor: 2.957

2.  Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island.

Authors:  L Abel; F Demenais
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

Review 3.  Leprosy and the human genome.

Authors:  Elizabeth A Misch; William R Berrington; James C Vary; Thomas R Hawn
Journal:  Microbiol Mol Biol Rev       Date:  2010-12       Impact factor: 11.056

4.  Association of C4B deficiency (C4B*Q0) with erythema nodosum in leprosy.

Authors:  I J de Messias; J Santamaria; M Brenden; A Reis; G Mauff
Journal:  Clin Exp Immunol       Date:  1993-05       Impact factor: 4.330

5.  The genetic epidemiology of leprosy in a Brazilian population.

Authors:  M F Feitosa; I Borecki; H Krieger; B Beiguelman; D C Rao
Journal:  Am J Hum Genet       Date:  1995-05       Impact factor: 11.025

6.  Genetic, household and spatial clustering of leprosy on an island in Indonesia: a population-based study.

Authors:  Mirjam I Bakker; Linda May; Mochammad Hatta; Agnes Kwenang; Paul R Klatser; Linda Oskam; Jeanine J Houwing-Duistermaat
Journal:  BMC Med Genet       Date:  2005-11-24       Impact factor: 2.103

Review 7.  Pauci- and Multibacillary Leprosy: Two Distinct, Genetically Neglected Diseases.

Authors:  Jean Gaschignard; Audrey Virginia Grant; Nguyen Van Thuc; Marianna Orlova; Aurélie Cobat; Nguyen Thu Huong; Nguyen Ngoc Ba; Vu Hong Thai; Laurent Abel; Erwin Schurr; Alexandre Alcaïs
Journal:  PLoS Negl Trop Dis       Date:  2016-05-24

8.  Leprosy among schoolchildren in the Amazon region: A cross-sectional study of active search and possible source of infection by contact tracing.

Authors:  Valderiza Lourenço Pedrosa; Luiz Claudio Dias; Enrique Galban; André Leturiondo; Jamile Palheta; Monica Santos; Milton Ozório Moraes; Carolina Talhari
Journal:  PLoS Negl Trop Dis       Date:  2018-02-26
  8 in total

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