Literature DB >> 511130

Sensitivity of Bloom's syndrome lymphocytes to ethyl methanesulfonate.

A B Krepinsky, J A Heddle, J German.   

Abstract

Ethyl methanesulfonate induced several times as many sister chromatid exchanges (SCE's) in lymphocytes from individuals affected with Bloom's syndrome as in lymphocytes from controls or heterozygotes. In cultures of cells from an individual with Bloom's syndrome who had two populations of lymphocytes circulating in his blood--'low' cells having normal spontaneous frequencies of SCE's and 'high' cells having elevated frequencies--only the high cells showed the increased sensitivity to ethyl methanesulfonate.

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Year:  1979        PMID： 511130     DOI： 10.1007/bf00390236

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  12 in total

1.  Bloom's syndrome. V. Surveillance for cancer in affected families.

Authors:  J German; D Bloom; E Passarge
Journal:  Clin Genet       Date:  1977-09       Impact factor: 4.438

2.  Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes.

Authors:  J German; S Schonberg; E Louie; R S Chaganti
Journal:  Am J Hum Genet       Date:  1977-05       Impact factor: 11.025

Review 3.  Repair deficient human disorders and cancer.

Authors:  R B Setlow
Journal:  Nature       Date:  1978-02-23       Impact factor: 49.962

4.  Bloom's syndrome. III. Analysis of the chromosome aberration characteristic of this disorder.

Authors:  J German; L P Crippa; D Bloom
Journal:  Chromosoma       Date:  1974       Impact factor: 4.316

5.  DNA damage and repair in light-sensitive human skin disease.

Authors:  J E Cleaver
Journal:  J Invest Dermatol       Date:  1970-03       Impact factor: 8.551

6.  Ultraviolet light sensitivity and delayed DNA-chain maturation in Bloom's syndrome fibroblasts.

Authors:  F Gianneli; P F Benson; S A Pawsey; P E Polani
Journal:  Nature       Date:  1977-02-03       Impact factor: 49.962

7.  Effect of cocultivation on sister chromatid exchange frequencies in Bloom's syndrome and normal fibroblast cells.

Authors:  R Tice; G Windler; J M Bary
Journal:  Nature       Date:  1978-06-15       Impact factor: 49.962

8.  Effects of mitomycin C on sister chromatid exchange in normal and Bloom's syndrome cells.

Authors:  Y Shiraishi; A A Sandberg
Journal:  Mutat Res       Date:  1978-02       Impact factor: 2.433

9.  The production of micronuclei from chromosome aberrations in irradiated cultures of human lymphocytes.

Authors:  P I Countryman; J A Heddle
Journal:  Mutat Res       Date:  1976-12       Impact factor: 2.433

10.  Chromosome aberrations and unscheduled DNA synthesis in X- and UV-irradiated lymphocytes from a boy with Bloom's syndrome and a man with xeroderma pigmentosum.

Authors:  H J Evans; A C Adams; J M Clarkson; J German
Journal:  Cytogenet Cell Genet       Date:  1978
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  25 in total

1.  Sources and structures of mitotic crossovers that arise when BLM helicase is absent in Drosophila.

Authors:  Matthew C LaFave; Sabrina L Andersen; Eric P Stoffregen; Julie K Holsclaw; Kathryn P Kohl; Lewis J Overton; Jeff Sekelsky
Journal:  Genetics       Date:  2013-10-30       Impact factor: 4.562

2.  Heterozygous carriers for Bloom syndrome exhibit a spontaneously increased micronucleus formation in cultured fibroblasts.

Authors:  B Frorath; U Schmidt-Preuss; U Siemers; M Zöllner; H W Rüdiger
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

Review 3.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

4.  Elevated spontaneous mutation rate in Bloom syndrome fibroblasts.

Authors:  S T Warren; R A Schultz; C C Chang; M H Wade; J E Trosko
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

5.  Functional deficiency of fibroblasts heterozygous for Bloom syndrome as specific manifestation of the primary defect.

Authors:  C R Bartram; H W Rüdiger; U Schmidt-Preuss; E Passarge
Journal:  Am J Hum Genet       Date:  1981-11       Impact factor: 11.025

6.  Rate of sister chromatid exchanges in Bloom syndrome fibroblasts reduced by co-cultivation with normal fibroblasts.

Authors:  H W Rüdiger; C R Bartram; W Harder; E Passarge
Journal:  Am J Hum Genet       Date:  1980-03       Impact factor: 11.025

7.  Presence of abnormally high incidences of sister chromatid exchanges in three successive cell cycles in Bloom's syndrome lymphocytes.

Authors:  H Tsuji; T Kojima
Journal:  Chromosoma       Date:  1985       Impact factor: 4.316

8.  Loss of high frequency of sister chromatid exchanges in Epstein-Barr virus-established lymphoblastoid cell lines from two patients with Bloom's syndrome.

Authors:  T Hashimoto; S Gamo; J Furuyama; H Chiyo
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

9.  Different mutations are responsible for the elevated sister-chromatid exchange frequencies characteristic of Bloom's syndrome and hamster EM9 cells.

Authors:  J H Ray; E Louie; J German
Journal:  Proc Natl Acad Sci U S A       Date:  1987-04       Impact factor: 11.205

10.  Mutagen-induced sister chromatid exchange rate in Bloom syndrome remains unaltered in the presence of Bloom corrective factor.

Authors:  U Schmidt-Preuss; P Maack; C R Bartram; H W Rüdiger
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132
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