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Literature DB >> 511110

Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone.

V Brantl, H Teschemacher, A Henschen, F Lottspeich.

Abstract

A material which displayed opioid activity in the guinea pig ileum longitudinal muscle-myenteric plexus preparation was extracted from an enzymatic casein digest into chloroform/methanol. The extract was roughly purified by adsorption/desorption procedures using charcoal and Amberlite XAD-2 resin as adsorbents. A high degree of purity was achieved by high-pressure liquid chromatography of the material on muBondapak C18 and mu-Porasil columns and finally by gel filtration chromatography on a Bio-Gel P-2 column. Several pronase-resistant compounds with opioid activity were obtained.

Entities: Chemical Species

Mesh：

Substances：

Year: 1979 PMID： 511110 DOI： 10.1515/bchm2.1979.360.2.1211

Source DB: PubMed Journal: Hoppe Seylers Z Physiol Chem ISSN： 0018-4888

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Cited

33 in total

Review 1. The effects of ante- and postnatal hypoxia on the central nervous system and their correction with peptide hormones.

Authors: M V Maslova; A S Maklakova; N A Sokolova; I P Ashmarin; E N Goncharenko; Ya V Krushinskaya
Journal: Neurosci Behav Physiol Date: 2003-07

2. Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.

Authors: Haruki Kitazawa; Kumiko Yonezawa; Masanori Tohno; Takeshi Shimosato; Yasushi Kawai; Tadao Saito; Ji Ming Wang
Journal: Int Immunopharmacol Date: 2007-05-21 Impact factor: 4.932

3. Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).

Authors: M Kampa; S Loukas; A Hatzoglou; P Martin; P M Martin; E Castanas
Journal: Biochem J Date: 1996-11-01 Impact factor: 3.857

Novel opioid peptides derived from casein (beta-casomorphins). I. Isolation from bovine casein peptone.

Review 1. The effects of ante- and postnatal hypoxia on the central nervous system and their correction with peptide hormones.

2. Enzymatic digestion of the milk protein beta-casein releases potent chemotactic peptide(s) for monocytes and macrophages.

3. Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human alpha S1 casein (alpha S1-casomorphin, and alpha S1-casomorphin amide).

Review 4. Biologically active peptides in milk proteins.

5. Immunoreactive opioid peptides in human breast cancer.

Review 6. Opioid peptides and glucose metabolism.

Review 7. Casein, a prohormone with an immunomodulating role for the newborn?

Review 8. A brief history of opiates, opioid peptides, and opioid receptors.

9. Modulation of post-prandial insulin release by ingested opiate-like substances in dogs.

10. A uniform molecular model of delta opioid agonist and antagonist pharmacophore conformations.