Carcinomas of the liver in female mice fed toluene-2,4-diamine.

B6C3F1 female mice fed 100 or 200 ppm of the aromatic amine, toluene-2,4-diamine, developed significant number of carcinomas of the liver. The carcinomas varied from well-differentiated to poorly differentiated. Treated mice also developed hyperplastic hepatic nodules, but cirrhosis was not observed. Hyperplastic nodules, carcinomas, and cirrhosis of the liver have been described in rats ingesting toluene-2,4-diamine.