Literature DB >> 5105675

DDT administered to neonatal rats induces persistent estrus syndrome.

W L Heinrichs, R J Gellert, J L Bakke, N L Lawrence.   

Abstract

The o,p'-isomer of the insecticide DDT when injected into neonatal female rats significantly advanced puberty, induced persistent vaginal estrus after a period of normal estrous cycles, and caused the ovaries to develop follicular cysts and a reduced number of corpora lutea. The uterotropic response to administered estradiol was reduced, and the female pattern of mating behavior was slightly disturbed. Residues of DDT in ovarian, brain, and adipose tissues of the adult animals were the same in both treated and control groups.

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Year:  1971        PMID： 5105675     DOI： 10.1126/science.173.3997.642

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Effects of DDT on reproduction in multiple generations of beagle dogs.

Authors:  A Ottoboni; G D Bissell; A C Hexter
Journal:  Arch Environ Contam Toxicol       Date:  1977       Impact factor: 2.804

2.  The effect of DDT and PCB on lipid metabolism in E. coli and B. fragilis.

Authors:  D E Greer; J E Keil; L W Stillway; S H Sandifer
Journal:  Bull Environ Contam Toxicol       Date:  1974-09       Impact factor: 2.151

3.  Reproduction in female rats born to DDT-treated parents.

Authors:  J G Clement; A B Okey
Journal:  Bull Environ Contam Toxicol       Date:  1974-09       Impact factor: 2.151

4.  Environmental toxicant effects on neuroendocrine function.

Authors:  A C Gore
Journal:  Endocrine       Date:  2001-03       Impact factor: 3.633

5.  Differential behavioral responses of male and female adult rats treated with five psychotropic drugs in the neonatal stage.

Authors:  N M Fonseca; A B Sell; E A Carlini
Journal:  Psychopharmacologia       Date:  1976-04-15

Review 6.  Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes.

Authors:  Wendy N Jefferson; Carmen J Williams
Journal:  Reprod Toxicol       Date:  2010-10-15       Impact factor: 3.143

Review 7.  Environmental endocrine disruption: an effects assessment and analysis.

Authors:  T M Crisp; E D Clegg; R L Cooper; W P Wood; D G Anderson; K P Baetcke; J L Hoffmann; M S Morrow; D J Rodier; J E Schaeffer; L W Touart; M G Zeeman; Y M Patel
Journal:  Environ Health Perspect       Date:  1998-02       Impact factor: 9.031

8.  Pituitary function following treatment with reproductive toxins.

Authors:  R L Cooper; J M Goldman; G L Rehnberg
Journal:  Environ Health Perspect       Date:  1986-12       Impact factor: 9.031

9.  Low concentrations of o,p'-DDT inhibit gene expression and prostaglandin synthesis by estrogen receptor-independent mechanism in rat ovarian cells.

Authors:  Jing Liu; Meirong Zhao; Shulin Zhuang; Yan Yang; Ye Yang; Weiping Liu
Journal:  PLoS One       Date:  2012-11-27       Impact factor: 3.240

10.  Fetal PCB syndrome: clinical features, intrauterine growth retardation and possible alteration in calcium metabolism.

Authors:  F Yamashita; M Hayashi
Journal:  Environ Health Perspect       Date:  1985-02       Impact factor: 9.031
  10 in total

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