Literature DB >> 5105670

Three size-classes of intracellular adenovirus deoxyribonucleic acid.

B T Burlingham, W Doerfler.   

Abstract

When human adenovirus type 2 or 12 infects cells, either productively or non-productively, three classes of viral deoxyribonucleic acid (DNA) are found within the cells: (i) viral DNA which cosediments with DNA extracted from infectious adenovirions at 31.3S for adenovirus type 2 and at 29.0S for adenovirus type 12, (ii) viral DNA which sediments at about 18S, and (iii) viral DNA which sediments at >45S and is apparently integrated into the cellular DNA. A precursor-product relationship is suggested as a working hypothesis; the intact viral DNA is hydrolyzed to slowly sedimenting DNA and the slowly sedimenting DNA is integrated into the cellular DNA. Both the parental and the newly synthesized viral DNA are altered by this route. The intact viral DNA within the cells apparently is cleaved into the slowly sedimenting DNA by a preformed enzyme.

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Year:  1971        PMID： 5105670      PMCID： PMC356189     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Sedimentation rate as a measure of molecular weight of DNA.

Authors:  E BURGI; A D HERSHEY
Journal:  Biophys J       Date:  1963-07       Impact factor: 4.033

2.  Biochemical studies on adenovirus multiplication. IV. Isolation, purification, and chemical analysis of adenovirus.

Authors:  M GREEN; M PINA
Journal:  Virology       Date:  1963-05       Impact factor: 3.616

3.  A method for determining the sedimentation behavior of enzymes: application to protein mixtures.

Authors:  R G MARTIN; B N AMES
Journal:  J Biol Chem       Date:  1961-05       Impact factor: 5.157

4.  A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.

Authors:  K BURTON
Journal:  Biochem J       Date:  1956-02       Impact factor: 3.857

5.  Structure and development of viruses as observed in the electron microscope. V. Entry and uncoating of adenovirus.

Authors:  C Morgan; H S Rosenkranz; B Mednis
Journal:  J Virol       Date:  1969-11       Impact factor: 5.103

6.  Early events in the interaction of adenoviruses with HeLa cells. I. Penetration of type 5 and intracellular release of the DNA genome.

Authors:  Y Chardonnet; S Dales
Journal:  Virology       Date:  1970-03       Impact factor: 3.616

7.  Changes in the structure and activity of lambda DNA in a superinfected immune bacterium.

Authors:  V C Bode; A D Kaiser
Journal:  J Mol Biol       Date:  1965-12       Impact factor: 5.469

8.  Denaturation pattern of the DNA of adenovirus type 2 as determined by electron microscopy.

Authors:  W Doerfler; A K Kleinschmidt
Journal:  J Mol Biol       Date:  1970-06-28       Impact factor: 5.469

9.  The effect of heat on the anatomy of the adenovirus.

Authors:  W C Russell; R C Valentine; H G Pereira
Journal:  J Gen Virol       Date:  1967-10       Impact factor: 3.891

10.  A membrane-filter technique for the detection of complementary DNA.

Authors:  D T Denhardt
Journal:  Biochem Biophys Res Commun       Date:  1966-06-13       Impact factor: 3.575
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  20 in total

1.  Association of endonuclease activity with serotypes belonging to the three subgroups of human adenoviruses.

Authors:  R G Marusyk; A R Morgan; G Wadell
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

2.  Transcription of the genome of adenovirus type 12. I. Viral mRNA in abortively infected and transformed cells.

Authors:  J Ortin; W Doerfler
Journal:  J Virol       Date:  1975-01       Impact factor: 5.103

3.  Adenovirus early function required for protection of viral and cellular DNA.

Authors:  J C D'Halluin; C Allart; C Cousin; P A Boulanger; G R Martin
Journal:  J Virol       Date:  1979-10       Impact factor: 5.103

4.  Some adenovirus DNA is associated with the DNA of permissive cells during productive or restricted growth.

Authors:  C Tyndall; H B Younghusband; A J Bellett
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

5.  Loss of supercoiled viral DNA after infection of permissive cells by simian virus 40.

Authors:  G D Frenkel
Journal:  J Virol       Date:  1977-01       Impact factor: 5.103

6.  Differences between the integration of avian myeloblastosis virus DNA in leukemic cells and of endogenous viral DNA in normal chicken cells.

Authors:  R M Evans; M A Baluda; M Shoyab
Journal:  Proc Natl Acad Sci U S A       Date:  1974-08       Impact factor: 11.205

7.  Evidence for the presence of RNA in the purified virions of vaccinia virus.

Authors:  G Roening; J A Holowczak
Journal:  J Virol       Date:  1974-09       Impact factor: 5.103

8.  Intermediates in the synthesis of type 2 adenovirus deoxyribonucleic acid.

Authors:  M S Horwitz
Journal:  J Virol       Date:  1971-11       Impact factor: 5.103

9.  Intracellular forms of adenovirus DNA. 3. Integration of the DNA of adenovirus type 2 into host DNA in productively infected cells.

Authors:  H Burger; W Doerfler
Journal:  J Virol       Date:  1974-05       Impact factor: 5.103

10.  Intracellular forms of Adenovirus DNA. II. Isolation in dye-buoyant density gradients of a DNA-RNA complex from KB cells infected with Adenovirus type 2.

Authors:  W Doerfler; U Lundholm; U Rensing; L Philipson
Journal:  J Virol       Date:  1973-10       Impact factor: 5.103
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