Literature DB >> 510382

Vasoactive intestinal peptide inhibits release of somatostatin from hypothalamus in vitro.

J Epelbaum, L Tapia-Arancibia, J Besson, W H Rotsztejn, C Kordon.   

Abstract

The effect of vasoactive intestinal peptide (VIP) was studied on the release of somatostatin (SRIF) from slices of several regions of the rat brain in vitro. VIP induced a dose-dependent inhibition of SRIF release from mediobasal hypothalamic slices but did not interfere with SRIF release from preoptic area, amygdala or cortex. VIP inhibition had an apparent affinity: Kd = 6.8 +/- 3.9 x 10(-11) M. Secretin had a similar effect but at 600-fold higher concentrations (Kd secretin = 4.2 +/- 0.6 x 10(-8) M). Gucagon was ineffective in concentrations ranging from 10(-10) M to 10(-7) M. The data are consistent with a role of VIP in the hypothalamic control of growth hormone secretion.

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Year:  1979        PMID： 510382     DOI： 10.1016/0014-2999(79)90323-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  Vasoactive intestinal peptide.

Authors:  S I Said
Journal:  J Endocrinol Invest       Date:  1986-04       Impact factor: 4.256

2.  Modulation of cholinergic neurotransmission by the peptide VIP, VIP antiserum and VIP antagonists in dog and cat trachea.

Authors:  H Hakoda; Y Ito
Journal:  J Physiol       Date:  1990-09       Impact factor: 5.182

3.  The PHI (PHI-27)/corticotropin-releasing factor/enkephalin immunoreactive hypothalamic neuron: possible morphological basis for integrated control of prolactin, corticotropin, and growth hormone secretion.

Authors:  T Hökfelt; J Fahrenkrug; K Tatemoto; V Mutt; S Werner; A L Hulting; L Terenius; K J Chang
Journal:  Proc Natl Acad Sci U S A       Date:  1983-02       Impact factor: 11.205

Review 4.  Neuroendocrine regulation of thyrotropin-releasing hormone (TRH) in the tuberoinfundibular system.

Authors:  R Toni; R M Lechan
Journal:  J Endocrinol Invest       Date:  1993-10       Impact factor: 4.256

Review 5.  VIP: molecular biology and neurobiological function.

Authors:  I Gozes; D E Brenneman
Journal:  Mol Neurobiol       Date:  1989       Impact factor: 5.590

Review 6.  The role of vasoactive intestinal polypeptide (VIP) as a hypothalamic neurohormone.

Authors:  S Nicosia; D Oliva; G Giannattasio; A Spada
Journal:  J Endocrinol Invest       Date:  1983-06       Impact factor: 4.256

7.  The human brain somatostatin interactome: SST binds selectively to P-type family ATPases.

Authors:  Michael Solarski; Declan Williams; Mohadeseh Mehrabian; Hansen Wang; Holger Wille; Gerold Schmitt-Ulms
Journal:  PLoS One       Date:  2019-05-28       Impact factor: 3.240

8.  Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide.

Authors:  D E Brenneman; E A Neale; G A Foster; S W d'Autremont; G L Westbrook
Journal:  J Cell Biol       Date:  1987-06       Impact factor: 10.539
  8 in total

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