Literature DB >> 5101343

Effect of actinomycin D on Paget's disease of bone.

J J Fennelly, J F Groarke.   

Abstract

Four patients with active Paget's disease were treated with the RNA inhibitor actinomycin D. Three were clinically improved after treatment; the fourth had multiple collapsed vertebrae and showed no symptomatic improvement. Striking changes took place in urinary calcium and hydroxyproline, in serum alkaline phosphatase, and to a less extent in serum calcium and phosphate. These studies are continuing and are being compared with the effects of mithramycin.

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Year:  1971        PMID： 5101343      PMCID： PMC1795089          DOI： 10.1136/bmj.1.5746.423

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  14 in total

1.  A specific method for the analysis of hydroxyproline in tissues and urine.

Authors:  D J PROCKOP; S UDENFRIEND
Journal:  Anal Biochem       Date:  1960-11       Impact factor: 3.365

2.  [Comparative study of colorimetric determinations of phosphorus. IV. Determination of orthophosphate in the presence of phosphoric acid esters; new methods].

Authors:  J L DELSAL; H MANHOURI
Journal:  Bull Soc Chim Biol (Paris)       Date:  1958

3.  Actinomycin D and transverse lines of growing bones.

Authors:  D Aarskog; A Hexeberg
Journal:  Acta Paediatr Scand       Date:  1968-11

4.  Effects of calcitonin on patients with Paget's disease, thyrotoxicosis, or hypercalcaemia.

Authors:  O L Bijvoet; J van der Sluys Veer; A P Jansen
Journal:  Lancet       Date:  1968-04-27       Impact factor: 79.321

5.  Effect of actinomycin D on epiphyseal plate of mice. A histological and 35S-autoradiographic study.

Authors:  A Hulth; L Lindberg
Journal:  Acta Pathol Microbiol Scand       Date:  1968

6.  Effects of mithramycin on Paget's disease of bone.

Authors:  W G Ryan; T B Schwartz; C P Perlia
Journal:  Ann Intern Med       Date:  1969-03       Impact factor: 25.391

7.  Homeostasis of plasma calcium: effects of actinomycin D, parathyroidectomy and thyrocalcitonin.

Authors:  A H Tashjian
Journal:  Endocrinology       Date:  1965-08       Impact factor: 4.736

8.  The importance of varying molecular size, differential heat and urea inactivation of phosphatase in the identification of disease patterns.

Authors:  J J Fennelly; J Dunne; K McGeeney; L Chong; M FitzGerald
Journal:  Ann N Y Acad Sci       Date:  1969-10-14       Impact factor: 5.691

9.  Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease.

Authors:  V Parsons; M Baum; M Self
Journal:  Br Med J       Date:  1967-02-25

10.  Effect of frusemide on calcium excretion.

Authors:  J A Tambyah; M K Lim
Journal:  Br Med J       Date:  1969-03-22
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  10 in total

1.  Medical staff conference. Paget disease of bone.

Authors: 
Journal:  West J Med       Date:  1978-09

2.  Chemical and morphologic alterations of rabbit bone induced by adriamycin.

Authors:  D M Young; J L Fioravanti; H M Olson; D J Prieur
Journal:  Calcif Tissue Res       Date:  1975-07-04

3.  Intravenous glucagon.

Authors:  J J Fennelly
Journal:  Br Med J       Date:  1972-04-01

4.  Clinical and biochemical studies of Paget's disease of bone with emphasis on the effects of RNA inhibitors actinomycin D and mithrawycin.

Authors:  J J Fennelly
Journal:  Ir J Med Sci       Date:  1971-10       Impact factor: 1.568

Review 5.  Drugs for disorders of bone: pharmacological and clinical considerations.

Authors:  G R Mundy; L G Raisz
Journal:  Drugs       Date:  1974       Impact factor: 9.546

6.  Compression of cord by Paget's disease.

Authors: 
Journal:  Br Med J       Date:  1973-05-12

7.  Pseudouridine excretion--a reflection of high RNA turnover in Paget's disease.

Authors:  J J Fennelly; A Hogan
Journal:  Ir J Med Sci       Date:  1972 Jul-Sep       Impact factor: 1.568

8.  Mithramycin therapy in Paget's disease.

Authors:  A S Russell; B C Lentle
Journal:  Can Med Assoc J       Date:  1974-02-16       Impact factor: 8.262

9.  Treatment of Paget's disease of bone with synthetic salmon calcitonin.

Authors:  J A Kanis; D B Horn; R D Scott; J A Strong
Journal:  Br Med J       Date:  1974-09-21

Review 10.  Diagnosis and Management of Paget's Disease of Bone in Adults: A Clinical Guideline.

Authors:  Stuart H Ralston; Luis Corral-Gudino; Cyrus Cooper; Roger M Francis; William D Fraser; Luigi Gennari; Núria Guañabens; M Kassim Javaid; Robert Layfield; Terence W O'Neill; R Graham G Russell; Michael D Stone; Keith Simpson; Diana Wilkinson; Ruth Wills; M Carola Zillikens; Stephen P Tuck
Journal:  J Bone Miner Res       Date:  2019-02-25       Impact factor: 6.741
  10 in total

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