Literature DB >> 5099604

Aggregations of 35-nanometer particles associated with neuronal cytopathic changes in natural scrapie.

A Bignami, H B Parry.   

Abstract

Neuronal vacuolation and intravacuolar budding of vesicles and cytoplasmic processes appear to be the most characteristic cellular lesion in natural scrapie, a chronic degenerative disease of the central nervous system of sheep which is transmissible by injection. Membrane-bound accumulations of the 35-nm particles are fotnd in the cytoplasmic processes that project inside the vacuoles of the neuronal perikaryon. Such particles are present only in a small number of vacuolated neurons.

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Year:  1971        PMID： 5099604     DOI： 10.1126/science.171.3969.389

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  18 in total

1.  Intranuclear inclusions in a case of Creutzfeldt-Jakob disease: an ultrastructural study.

Authors:  C M Payne; W A Sibley
Journal:  Acta Neuropathol       Date:  1975       Impact factor: 17.088

2.  Rapid chemical decontamination of infectious CJD and scrapie particles parallels treatments known to disrupt microbes and biofilms.

Authors:  Sotirios Botsios; Sarah Tittman; Laura Manuelidis
Journal:  Virulence       Date:  2015       Impact factor: 5.882

3.  Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.

Authors:  M P McKinley; R K Meyer; L Kenaga; F Rahbar; R Cotter; A Serban; S B Prusiner
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

4.  Proteomic analysis of host brain components that bind to infectious particles in Creutzfeldt-Jakob disease.

Authors:  Terry Kipkorir; Christopher M Colangelo; Laura Manuelidis
Journal:  Proteomics       Date:  2015-06-09       Impact factor: 3.984

5.  Ultrastructural changes in the progress of natural Scrapie regardless fixation protocol.

Authors:  Rocío Sarasa; Concepción Junquera; Adolfo Toledano; Juan José Badiola; Marta Monzón
Journal:  Histochem Cell Biol       Date:  2015-02-28       Impact factor: 4.304

6.  An electron microscopic study of natural scrapie sheep brain: further observations on virus-like particles and paramyxovirus-like tubules.

Authors:  H K Narang
Journal:  Acta Neuropathol       Date:  1974       Impact factor: 17.088

7.  The ataxic (cerebellar) form of Creutzfeldt-Jakob disease.

Authors:  K Jellinger; W D Heiss; E Deisenhammer
Journal:  J Neurol       Date:  1974       Impact factor: 4.849

8.  Specific membranous structures associated with the replication of group A arboviruses.

Authors:  P M Grimley; J G Levin; I K Berezesky; R M Friedman
Journal:  J Virol       Date:  1972-09       Impact factor: 5.103

Review 9.  On the biology of prions.

Authors:  S B Prusiner; R Gabizon; M P McKinley
Journal:  Acta Neuropathol       Date:  1987       Impact factor: 17.088

10.  Tubulovesicular structures in human and experimental Creutzfeldt-Jakob disease.

Authors:  P P Liberski; H Budka; E Sluga; M Barcikowska; H Kwiecinski
Journal:  Eur J Epidemiol       Date:  1991-09       Impact factor: 8.082
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