Literature DB >> 5097577

Ligand kinetics in hemoglobin Hiroshima.

R L Nagel, Q H Gibson, H B Hamilton.   

Abstract

Hemoglobin Hiroshima is an electrophoretically fast-moving variant with a fourfold increase in oxygen affinity and a decreased Bohr effect. Based on a decreased rate of dissociation of O(2) in the presence of dithionite and an increased rate of binding of CO by the deoxy form, we have concluded that the kinetic basis of the high affinity exhibited by Hb Hiroshima is the concurrence of a faster combination rate and a slower dissociation rate for ligands.

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Year:  1971        PMID： 5097577      PMCID： PMC442077          DOI： 10.1172/JCI106666

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  Spin-labelled haemoglobins: a structural interpretation of electron paramagnetic resonance spectra based on X-ray analysis.

Authors:  J K Moffat
Journal:  J Mol Biol       Date:  1971-01-28       Impact factor: 5.469

2.  A practical automatic data acquisition system for stopped-flow spectrophotometry.

Authors:  R J DeSa; Q H Gibson
Journal:  Comput Biomed Res       Date:  1969-10

3.  Oxygen-equilibrium characteristics of abnormal hemoglobin Hiroshima (alpha-2 beta-2 143 Asp).

Authors:  K Imai
Journal:  Arch Biochem Biophys       Date:  1968-09-20       Impact factor: 4.013

4.  The reaction of oxygen with hemoglobin and the kinetic basis of the effect of salt on binding of oxygen.

Authors:  Q H Gibson
Journal:  J Biol Chem       Date:  1970-07-10       Impact factor: 5.157

5.  Kinetics of the reaction of hemoglobin with ethylisocyanide. Interpretation of the results within a dimer scheme.

Authors:  E Antonini; M Brunori
Journal:  J Biol Chem       Date:  1970-10-25       Impact factor: 5.157

6.  Stereochemistry of cooperative effects in haemoglobin.

Authors:  M F Perutz
Journal:  Nature       Date:  1970-11-21       Impact factor: 49.962

7.  The binding of hemoglobin to haptoglobin and its relation to subunit dissociation of hemoglobin.

Authors:  R L Nagel; Q H Gibson
Journal:  J Biol Chem       Date:  1971-01-10       Impact factor: 5.157

8.  Hemoglobin Hiroshima (beta-143 histidine--aspartic acid): a newly identified fast moving beta chain variant associated with increased oxygen affinity and compensatory erythremia.

Authors:  H B Hamilton; I Iuchi; T Miyaji; S Shibata
Journal:  J Clin Invest       Date:  1969-03       Impact factor: 14.808

9.  Apparatus for rapid and sensitive spectrophotometry.

Authors:  Q H Gibson; L Milnes
Journal:  Biochem J       Date:  1964-04       Impact factor: 3.857

10.  Tyrosine ionization in human carbon monoxide and deoxyhemoglobins.

Authors:  R L Nagel; H M Ranney; L L Kucinskis
Journal:  Biochemistry       Date:  1966-06       Impact factor: 3.162
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