| Literature DB >> 5090761 |
T J McKenna, J F Donohoe, T G Brien, J J Healy, B S Canning, F P Muldowney.
Abstract
Three pharmacological agents in use as "potassium-sparing" drugs have been tested by serial measurements of total exchangeable potassium (K(E)) during 4 to 12 weeks of oral diuretic therapy in hypertensive subjects. Triamterene seemed ineffective in the dosage used (50 mg twice daily). Spironolactone (25 mg twice daily) reduced K loss to a considerable extent, while Slow-K (32 mEq daily) completely reversed previous K(E) deficits. Plasma K levels were a poor indication of degree of K(E) restoration.Entities:
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Year: 1971 PMID： 5090761 PMCID： PMC1796357 DOI： 10.1136/bmj.2.5764.739
Source DB: PubMed Journal: Br Med J ISSN： 0007-1447