Literature DB >> 509059

Modulation of the immune response and control of tumour spread by a new synthetic compound.

R E Falk, L Makowka, N Nossal, J A Falk, J E Fields, S S Asculai.   

Abstract

A small molecular weight biofunctional polymer, NED 137, has been investigated for its anti-neoplastic effect. Through its effect on the immune system, particularly the induction of B cell differentiation to antibody producing cells, this synthetic compound can retard tumour growth and prevent the development of distant metastases. Reactivity to tumour developed following administration of the NED 137. No toxicity has been observed. The polymer NED 137 is now being tested in phase I and phase II clinical trials.

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Year:  1979        PMID: 509059     DOI: 10.1002/bjs.1800661208

Source DB:  PubMed          Journal:  Br J Surg        ISSN: 0007-1323            Impact factor:   6.939


  2 in total

1.  Nonspecific and selective stimulation of the immune system in the treatment of carcinoma in humans.

Authors:  R E Falk; L Makowka; U Ambus; J A Falk; R Bugala; S Landi
Journal:  Can Med Assoc J       Date:  1983-06-15       Impact factor: 8.262

2.  Menningococcal antigens (MA): a novel immune stimulant in experimental neoplasia.

Authors:  J A Teodorczyk-Injeyan; B G Sparkes; J M Dupuy; V V Micusan; R E Falk
Journal:  Cancer Immunol Immunother       Date:  1983       Impact factor: 6.968

  2 in total

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