Literature DB >> 508781

Dietary regulation of 3-hydroxy-3-methylglutaryl-CoA reductase from rat intestine.

W J Bochenek, J B Rodgers.   

Abstract

The effect of dietary cholesterol on rat intestinal 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) varied depending upon whether animals received the dietary cholesterol with polyunsaturated or saturated fats. When cholesterol was fed with polyunsaturates, the enzyme activity in both the jejunum and ileum was significantly suppressed, whereas only the enzyme in the jejunum was significantly suppressed when cholesterol was given with saturated fats. It is concluded that dietary cholesterol has a negative feedback effect on intestinal cholesterol synthesis.

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Year:  1979        PMID： 508781     DOI： 10.1016/0005-2760(79)90130-9

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells.

Authors:  N T Kam; E Albright; S Mathur; F J Field
Journal:  Biochem J       Date:  1990-12-01       Impact factor: 3.857

2.  Effect of fat and microflora on hepatic, small intestinal and colonic HMG CoA reductase, cytochrome P450 and cytochrome B5.

Authors:  P Smith-Barbaro; D Hanson; B S Reddy
Journal:  Lipids       Date:  1981-03       Impact factor: 1.880

3.  3-Hydroxy-3-methylglutaryl-coenzyme A reductase in normal and dystrophic hamsters.

Authors:  M C Greenough; R J Boegman
Journal:  Biochem J       Date:  1982-03-01       Impact factor: 3.857

4.  Effect of the type of diet on the distribution of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in rat small intestine.

Authors:  M Sugano; Y Fujisaki
Journal:  Experientia       Date:  1980-12-15

5.  Glucomannan- and glucomannan plus spirulina-enriched pork affect liver fatty acid profile, LDL receptor expression and antioxidant status in Zucker fa/fa rats fed atherogenic diets.

Authors:  Laura González-Torres; Cátia Matos; Miguel Vázquez-Velasco; Jorge A Santos-López; Iria Sánchez-Martínez; Camino García-Fernández; Sara Bastida; Juana Benedí; Francisco J Sánchez-Muniz
Journal:  Food Nutr Res       Date:  2016-12-20       Impact factor: 3.894
  5 in total

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