A characteristic membrane protein of liver peroxisomes inducible by clofibrate.

In sodium dodecyl sulfate polyacrylamide electrophoresis the membranes of rat liver peroxisomes show nine main protein bands (40 000--100 000 dalton); the 40 000-dalton polypeptide cannot be resolved from the membrane by deoxycholate. Treatment of the rats with clofibrate largely increases this protein and another one (about 80 000 dalton) in the peroxisomal but not in the endoplasmic reticulum membrane. Proliferation of peroxisomes seems to be connected with the insertion of specific proteins into the membrane.