Literature DB >> 5086904

Bacteriological and pathological study of animals given Freund adjuvant.

R H Rigdon, T Schadewald.   

Abstract

Freund complete adjuvant, with allegedly "killed and dried" Mycobacterium butyricum added (intramuscularly in rabbits and intraperitoneally in mice), produced a local granulomatous lesion and frequently a similar lesion in the viscera. Acid-fast bacilli were present in these lesions, and in some animals M. butyricum was obtained in culture. When this culture was inoculated in mice, a similar lesion developed. Pathological lesions with similar acid-fast organisms also were observed by us in rabbits given Freund complete adjuvant by two other investigators.

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Year:  1972        PMID： 5086904      PMCID： PMC380627          DOI： 10.1128/am.24.4.634-637.1972

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  8 in total

1.  Hepatic granulomas induced in guinea-pigs by Freund's adjuvant with and without homologous liver.

Authors:  R I JAHIEL; D KOFLER
Journal:  Br J Exp Pathol       Date:  1961-08

2.  Stimulation of the reticuloendothelial system in the rabbit by Freund's adjuvant.

Authors:  J C RUPP; R D MOORE; M D SCHOENBERG
Journal:  Arch Pathol       Date:  1960-07

3.  Development of arthritis, periarthritis and periostitis in rats given adjuvants.

Authors:  C M PEARSON
Journal:  Proc Soc Exp Biol Med       Date:  1956-01

4.  Amyloidosis and renal lesion induced in mice by injection with Freund-type of adjuvant.

Authors:  S ROTHBARD; R F WATSON
Journal:  Proc Soc Exp Biol Med       Date:  1954-01

5.  The effect of paraffin oil and mycobacteria on antibody formation and sensitization; a review.

Authors:  J FREUND
Journal:  Am J Clin Pathol       Date:  1951-07       Impact factor: 2.493

6.  Amyloid in the gastrointestinal tract of mice.

Authors:  R H Rigdon; T Schadewald
Journal:  Tex Rep Biol Med       Date:  1972

7.  Amyloid. 3. A method for rapid induction of amyloidosis in mice.

Authors:  J S Ram; R A DeLellis; G G Glenner
Journal:  Int Arch Allergy Appl Immunol       Date:  1968

8.  Studies on antibody production. IV. The role of a wax fraction of Mycobacterium tuberculosis in adjuvant emulsions on the production of antibody to egg albumin.

Authors:  R G WHITE; A H COONS; J M CONNOLLY
Journal:  J Exp Med       Date:  1955-07-01       Impact factor: 14.307
  8 in total
  1 in total

1.  Effect of adjuvant vaccines on dengue virus type 2 immune ascitic fluid production.

Authors:  W C Gamble; E H George; M B Fears; D W Sanderlin; W A Chappell
Journal:  J Clin Microbiol       Date:  1985-03       Impact factor: 5.948
  1 in total

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