Literature DB >> 508680

Systemic absorption of topically applied chloramphenicol eyedrops.

G E Trope, J R Lawrence, V M Hind, J Bunney.   

Abstract

Five children under the age of 9 years had topical chloramphenicol drops administered 2-hourly to each eye for 5 to 7 days. Systemic absorption was not detected by 2 sensitive assays for the drug. The hazards of topical chloramphenicol and reports in the current literature are discussed.

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Year:  1979        PMID： 508680      PMCID： PMC1043594          DOI： 10.1136/bjo.63.10.690

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  6 in total

1.  BONE-MARROW HYPOPLASIA FOLLOWING USE OF CHLORAMPHENICOL EYE DROPS.

Authors:  R L ROSENTHAL; A BLACKMAN
Journal:  JAMA       Date:  1965-01-11       Impact factor: 56.272

2.  Bone marrow, blood and assay levels following medication of cats with chloramphenicol ophthalmic ointment.

Authors:  G H Conner; B N Gupta
Journal:  Vet Med Small Anim Clin       Date:  1973-08

3.  Chloramphenicol in aqueous humor after topical application.

Authors:  H Beasley; J J Boltralik; H A Baldwin
Journal:  Arch Ophthalmol       Date:  1975-03

4.  Quantitative gas-chromatographic flame-ionization method for chloramphenicol in human serum.

Authors:  C J Least; N J Wiegand; G F Johnson; H M Solomon
Journal:  Clin Chem       Date:  1977-02       Impact factor: 8.327

5.  Letter: Chloramphenicol eye-drops and marrow aplasia.

Authors:  G Carpenter
Journal:  Lancet       Date:  1975-08-16       Impact factor: 79.321

6.  Ocular penetration of chloramphenicol. Effects of route of administration.

Authors:  F J George; C Hanna
Journal:  Arch Ophthalmol       Date:  1977-05
  6 in total
  4 in total

Review 1.  Comparative review of topical ophthalmic antibacterial preparations.

Authors:  P Y Robert; J P Adenis
Journal:  Drugs       Date:  2001       Impact factor: 9.546

Review 2.  Ocular chloramphenicol and aplastic anaemia. Is there a link?

Authors:  S A Rayner; R J Buckley
Journal:  Drug Saf       Date:  1996-05       Impact factor: 5.606

Review 3.  Treatment of ocular infections with topical antibacterials.

Authors:  J P Leeming
Journal:  Clin Pharmacokinet       Date:  1999-11       Impact factor: 6.447

4.  Widespread ocular use of topical chloramphenicol: is there justifiable concern regarding idiosyncratic aplastic anaemia?

Authors:  C N McGhee; C N Anastas
Journal:  Br J Ophthalmol       Date:  1996-02       Impact factor: 4.638
  4 in total

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