Literature DB >> 50852

Studies on mouse Moloney virus induced tumours: I. The detection of p30 as a cytotoxic target on murine Moloney leukaemic spleen cells, and on an in vitro Moloney sarcoma line by antibody mediated cytotoxicity.

L B Epstein, R A Knight.   

Abstract

Antigenic determinants of p30, the most abundant internal virion protein of C type RNA viruses, were detected on the surface of spleen cells from mice bearing Moloney leukaemia and on an in vitro line of Moloney sarcoma, MSC. On both cell types, these determinants on the p30 molecules served as cytotoxic targets in a xenogenic complement dependent antibody mediated 51Cr release assay. Two antisera were used: a rat anti MLV -M induced lymphoma serum, and an antiserum raised in goats to either disrupted FeLV. The cytotoxic target antigens of these antisera were analysed by inhibition of cytotoxicity with viral and cellular proteins.

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Year:  1975        PMID： 50852      PMCID： PMC2009444          DOI： 10.1038/bjc.1975.90

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  17 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Tumor-specific antigen solubilized by hypertonic potassium chloride.

Authors:  M S Meltzer; E J Leonard; H J Rapp; T Borsos
Journal:  J Natl Cancer Inst       Date:  1971-09       Impact factor: 13.506

3.  Cell line derived from a murine sarcoma virus (Moloney Pseudotype)-induced tumor: cultural, antigenic, and virological properties.

Authors:  J G Massicot; W A Woods; M A Chirigos
Journal:  Appl Microbiol       Date:  1971-12

4.  Cell-surface and virion-envelope antigens shared by radiation leukemia virus (RadLV) and other murine c-type viruses.

Authors:  J F Ferrer
Journal:  Int J Cancer       Date:  1973-09-15       Impact factor: 7.396

5.  Localization of RNA tumor virus polypeptides. I. Isolation of further virus substructures.

Authors:  D P Bolognesi; R Luftig; J H Shaper
Journal:  Virology       Date:  1973-12       Impact factor: 3.616

6.  Structural proteins of mammalian oncogenic RNA viruses: multiple antigenic determinants of the major internal protein and envelope glycoprotein.

Authors:  M Strand; J T August
Journal:  J Virol       Date:  1974-01       Impact factor: 5.103

7.  Coexistence of intraspecies and interspecies specific antigenic determinants on the major structural polypeptide of mammalian C-type viruses.

Authors:  R V Gilden; S Oroszlan; R J Huebner
Journal:  Nat New Biol       Date:  1971-05-26

8.  Common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses.

Authors:  T Yoshiki; R C Mellors; W D Hardy
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

9.  Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses.

Authors:  G Geering; L J Old; E A Boyse
Journal:  J Exp Med       Date:  1966-10-01       Impact factor: 14.307

10.  Common cell surface antigen associated with mammalian C-type RNA viruses. Cell membrane-bound gs antigen.

Authors:  T Yoshiki; R C Mellors; W D Hardy; E Fleissner
Journal:  J Exp Med       Date:  1974-04-01       Impact factor: 14.307
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  2 in total

1.  Sequential changes of T- and B-cells, virus antigen expression and primary histologic tumor diagnosis in virus-induced lymphomagenesis of mice.

Authors:  G R Krueger; K M Fischer; H G Flesch
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1978-08-24

2.  Studies on mouse Moloney virus induced tumours: II. Detection of p30 in the serum of mice with Moloney leukaemia by in vitro blocking of complement dependent antibody mediated cytotoxicity.

Authors:  L B Epstein; R A Knight
Journal:  Br J Cancer       Date:  1975-05       Impact factor: 7.640
  2 in total

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