Literature DB >> 507793

High-pressure liquid chromatography analysis of antibiotic susceptibility disks.

R B Hagel, E H Waysek, W M Cort.   

Abstract

The analysis of antibiotic susceptibility disks by high-pressure liquid chromatography (HPLC) was investigated. Methods are presented for the potency determination of mecillinam, ampicillin, carbenicillin, and cephalothin alone and in various combinations. Good agreement between HPLC and microbiological data is observed for potency determinations with recoveries of greater than 95%. Relative standard deviations of lower than 2% are recorded for each HPLC method. HPLC methods offer improved accuracy and greater precision when compared to the standard microbiological methods of analysis for susceptibility disks.

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Year:  1979        PMID： 507793      PMCID： PMC352863          DOI： 10.1128/AAC.16.3.372

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Antibacterial activity of mecillinam.

Authors:  D S Reeves
Journal:  J Antimicrob Chemother       Date:  1977-07       Impact factor: 5.790

2.  Stability-indicating assay for mecillinam using high-pressure liquid chromatography.

Authors:  R B Hagel; E H Waysek; D Humphrey
Journal:  J Chromatogr       Date:  1979-03-11

3.  Rapid determination of serum 5-fluorocytosine levels by high-performance liquid chromatography.

Authors:  R B Diasio; M E Wilburn; S Shadomy; A Espinel-Ingroff
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191

4.  Metabolic disposition of cephalothin and deacetylcephalothin in children and adults: comparison of high-performance liquid chromatographic and microbial assay procedures.

Authors:  T F Rolewicz; B L Mirkin; M J Cooper; M W Anders
Journal:  Clin Pharmacol Ther       Date:  1977-12       Impact factor: 6.875

5.  Carbenicillin: chemistry and mode of action.

Authors:  K Butler; A R English; V A Ray; A E Timreck
Journal:  J Infect Dis       Date:  1970-09       Impact factor: 5.226

6.  Rapid determination of amoxycillin (clamoxyl) and ampicillin (penbritin) in body fluids of many by means of high-performance liquid chromatography.

Authors:  T B Vree; Y A Hekster; A M Baars; E Van der Kleijn
Journal:  J Chromatogr       Date:  1978-05-01

7.  Quantitation of antibiotics by high-pressure liquid chromatography: cephalothin.

Authors:  I Nilsson-Ehle; T T Yoshikawa; M C Schotz; L B Guze
Journal:  Antimicrob Agents Chemother       Date:  1978-02       Impact factor: 5.191
  7 in total
  1 in total

1.  Pharmacokinetics and Pharmacodynamics of Cefepime in Adults with Hematological Malignancies and Febrile Neutropenia after Chemotherapy.

Authors:  José C Álvarez; Sonia I Cuervo; Edelberto Silva; Jorge A Díaz; Lorena L Jiménez; Daniel S Parra; Julio C Gómez; Ricardo Sánchez; Jorge A Cortés
Journal:  Antibiotics (Basel)       Date:  2021-04-29
  1 in total

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