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Literature DB >> 5072238

Central and peripheral effects of propranolol and sotalol in normal human subjects.

Abstract

No unequivocal central effects were found with either +/--propranolol (120 mg) or +/--sotalol (240 mg) in acute dosage in normal subjects. Subjective feelings of drowsiness and muzziness were found with sotalol and both sotalol and propranolol caused subjects to feel more troubled. These changes were not accompanied by physiological or behavioural evidence of sedation. Adequate beta-adrenoceptor blockade was achieved as measured by a significant fall in pulse-rate on both active drugs but no other significant peripheral physiological changes occurred.

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Year: 1972 PMID： 5072238 PMCID： PMC1666163 DOI： 10.1111/j.1476-5381.1972.tb08113.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

12 in total

Central and peripheral effects of propranolol and sotalol in normal human subjects.

1. Pharmacological and toxicological properties of two new beta-adrenergic receptor antagonists.

2. Some effects of propranolol on the central nervous system.

3. Effect of deafferentation on human physiological tremor.

4. Tranquillizing effects of propranolol demonstrated in rats.

5. D-Propranolol and anxiety.

6. Hangover effect of hypnotics in man.

7. Residual effects of hypnotics.

8. Effect of beta-adrenergic blockade on finger tremor and Achilles reflex time in anxious and thyrotoxic patients.

9. Hallucinations and propranolol.

10. The effect of propranolol on anxiety.

1. W E Dixon Memorial Lecture. Beta-adrenoceptor blockade in hyperthyroidism and anxiety.

2. Screening procedures in volunteers and patients.

Review 3. Side effects and contraindications of beta-receptor blocking agents.

4. Comparison of bisoprolol and diazepam in the treatment of cardiac neurosis.

5. A comparison of some physiological and psychological effects of propranolol and diazepam in normal subjects.

6. Propranolol on tests of visual function and central nervous activity.

7. Propranolol, anxiety and the central nervous system.

Review 8. [Use of certain cardiological drugs in the treatment of schizophrenia: review of the literature].

9. Memory performance by mild hypertensives following beta-adrenergic blockade.

10. Central effects of beta-adrenoceptor antagonists. I--Performance and subjective assessments of mood.