Literature DB >> 5072235

A quantitative study of the anticholinergic action of several tricyclic antidepressants on the rat isolated fundal strip.

J Atkinson, H Ladinsky.   

Abstract

1. Investigations were carried out on the antagonism of the action of carbamylcholine chloride on the isolated fundus of the rat stomach by several tricyclic antidepressants.2. The anticholinergic potency of the compounds was in the order: GP 45437>amitriptyline>protriptyline>desmethylimipramine>opipramol. All of the antagonists were less effective than atropine.3. Statistical analysis was carried out to determine whether the theory of competitive antagonism would fit the data obtained.

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Year:  1972        PMID： 5072235      PMCID： PMC1666156          DOI： 10.1111/j.1476-5381.1972.tb08109.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  14 in total

1.  [COMPARATIVE PHARMACOLOGICAL INVESTIGATIONS WITH TOFRANIL, PERTOFRAN AND INSIDON].

Authors:  W THEOBALD; O BUECH; H A KUNZ; C MORPURGO; E G STENGER; G WILHELMI
Journal:  Arch Int Pharmacodyn Ther       Date:  1964-04-01

2.  [COMPARATIVE STUDIES ON ALTERATION OF VEGETATIVE FUNCTIONS BY PSYCHOPHARMACOLOGICAL AGENTS IN ACUTE ANIMAL EXPERIMENTS].

Authors:  W THEOBALD; O BUECH; H A KUNZ
Journal:  Arzneimittelforschung       Date:  1965-02

3.  Quantitative studies of antagonists for 5-hydroxytryptamine.

Authors:  J H GADDUM; K A HAMEED; D E HATHWAY; F F STEPHENS
Journal:  Q J Exp Physiol Cogn Med Sci       Date:  1955-01

4.  Cholinergic blockade as an approach to the development of new psychotropic agents.

Authors:  J H BIEL; P A NUHFER; W K HOYA; H A LEISER; L G ABOOD
Journal:  Ann N Y Acad Sci       Date:  1962-01-13       Impact factor: 5.691

5.  The physiological role of acetyl-cholinesterase (AChE) in sympathetic ganglia.

Authors:  R L VOLLE; G B KOELLE
Journal:  J Pharmacol Exp Ther       Date:  1961-08       Impact factor: 4.030

6.  The pharmacology of vascular smooth muscle.

Authors:  R F FURCHGOTT
Journal:  Pharmacol Rev       Date:  1955-06       Impact factor: 25.468

7.  Conformational similarities between molecular models of phenethylamine and of potent inhibitors of the uptake of tritiated norepinephrine by adrenergic nerves in rabbit aorta.

Authors:  R E Maxwell; E Chaplin; S B Eckhardt; J R Soares; G Hite
Journal:  J Pharmacol Exp Ther       Date:  1970-05       Impact factor: 4.030

8.  [Basic tricyclic oxyiminoethers and their pharmacological properties].

Authors:  G Aichinger; O Behner; F Hoffmeister; S Schütz
Journal:  Arzneimittelforschung       Date:  1969-06

9.  Some quantitative uses of drug antagonists.

Authors:  O ARUNLAKSHANA; H O SCHILD
Journal:  Br J Pharmacol Chemother       Date:  1959-03

10.  A sensitive method for the assay of 5-hydroxytryptamine.

Authors:  J R VANE
Journal:  Br J Pharmacol Chemother       Date:  1957-09
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  9 in total

1.  The effect of tricyclic antidepressants on cholinergic responses of single cortical neurones.

Authors:  P Bevan; C M Bradshaw; E Szabadi
Journal:  Br J Pharmacol       Date:  1975-01       Impact factor: 8.739

2.  [The effect of coffee and coffee components on the stomach muscle].

Authors:  J Atkinson
Journal:  Z Ernahrungswiss       Date:  1976-06

3.  The effects of the tricyclic antidepressants desipramine, doxepin and iprindole on the isolated perfused rabbit heart.

Authors:  N Barth; E Muscholl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1974       Impact factor: 3.000

4.  Proceedings: The dual action of tricyclic antidepressant drugs on responses of single cortical neurones to acetylcholine.

Authors:  P Bevan; C M Bradshaw; M H Roberts; E Szabadi
Journal:  Br J Pharmacol       Date:  1973-09       Impact factor: 8.739

5.  Structure-activity relationships for the anticholinoceptor action of tricyclic antidepressants.

Authors:  K Shein; S E Smith
Journal:  Br J Pharmacol       Date:  1978-04       Impact factor: 8.739

6.  Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.

Authors:  E El-Fakahany; E Richelson
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

7.  The effect of some antidepressants on prejunctional muscarinic receptors on the sympathetic nerves of the isolated rabbit ear artery.

Authors:  Y H Kwok; F Mitchelson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-07       Impact factor: 3.000

8.  Comparison of the effects of binodaline and amitriptyline on peripheral autonomic functions in healthy volunteers.

Authors:  J Longmore; E Szabadi; C M Bradshaw
Journal:  Br J Clin Pharmacol       Date:  1985-03       Impact factor: 4.335

9.  The effects of several muscarinic antagonists on pre- and postsynaptic receptors in the isolated rabbit heart.

Authors:  H Fuder; C Meiser; H Wormstall; E Muscholl
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-02       Impact factor: 3.000
  9 in total

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