Literature DB >> 5072230

Renal excretion of metolazone, a new diuretic.

E J Belair, A I Cohen, J Yelnosky.   

Abstract

1. Metolazone, a new diuretic, was found to be excreted by glomerular filtration and renal tubular secretion.2. The secretory mechanism was antagonized by probenecid but this did not affect the diuretic action of metolazone.

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Year:  1972        PMID: 5072230      PMCID: PMC1666149          DOI: 10.1111/j.1476-5381.1972.tb08104.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  6 in total

1.  RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID: A PHENOXYACETIC SALURETIC-DIURETIC AGENT.

Authors:  K H BEYER; J E BAER; J K MICHAELSON; H F RUSSO
Journal:  J Pharmacol Exp Ther       Date:  1965-01       Impact factor: 4.030

2.  Animal pharmacology of the new diuretics: benzothiadiazines, spirolactones, and phthalimidines.

Authors:  B RENNICK
Journal:  Ann N Y Acad Sci       Date:  1960-10-11       Impact factor: 5.691

3.  Plasma binding of thiopental in the nephrectomized rabbit.

Authors:  J D TAYLOR; R K RICHARDS; J C DAVIN; J ASHER
Journal:  J Pharmacol Exp Ther       Date:  1954-09       Impact factor: 4.030

4.  Antagonism to the diuretic action of SR 720-22.

Authors:  E J Belair; A R Borrelli; J Yelnosky
Journal:  Proc Soc Exp Biol Med       Date:  1969-06

5.  Pharmacology of SR 720-22.

Authors:  E Belair; F Kaiser; B Van Denburg; A Borelli; R Lawlor; R Panasevich; J Yelnosky
Journal:  Arch Int Pharmacodyn Ther       Date:  1969-01

6.  The renal pharmacology of metolazone, 2-methyl-3-O-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone.

Authors:  E J Belair
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1971-01
  6 in total
  2 in total

Review 1.  Diuretic combinations in refractory oedema states: pharmacokinetic-pharmacodynamic relationships.

Authors:  D A Sica; T W Gehr
Journal:  Clin Pharmacokinet       Date:  1996-03       Impact factor: 6.447

Review 2.  Diuretics. Clinical pharmacology and therapeutic use (Part I).

Authors:  A Lant
Journal:  Drugs       Date:  1985-01       Impact factor: 9.546

  2 in total

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