Electrooculographic (EOG) findings in manic-depressive illness.

An electrooculographic (EOG) study was carried out in 20 depressed (12 with retarded and eight with agitated depression) and in 12 manic patients. Compared with controls, EOG ratios obtained from our patient's groups differed significantly and were low in depressive and high in manic patients. Appropriate treatment (tricyclics to depressives and haloperidol to manics) restored EOG ratio values to control levels. The observed EOG changes in manic-depressive illness are discussed in terms of their origin and the involvement of a neuroendocrine, dopamine-controlled, mechanism is postulated.