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Literature DB >> 5066093

Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat.

Abstract

Rats maintained on an intermittent food schedule with an available ethanol solution drink to excess (13.1 grams of ethanol per kilogram of body weight, daily). Removal of ethanol produces symptoms of physical dependence including death from tonic-clonic seizures. Overindulgence in oral self-administration of an aqueous ethanol solution, resulting in unequivocal physical dependence, approximates a model of human alcoholism.

Entities: Chemical Disease Species

Mesh：

Substances：
Ethanol

Year: 1972 PMID： 5066093 DOI： 10.1126/science.177.4051.811

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

37 in total

1. Potentiation of ethanol withdrawal by prior dependence.

Authors: T B Baker; D S Cannon
Journal: Psychopharmacology (Berl) Date: 1979-01-31 Impact factor: 4.530

Review 2. Preclinical studies of alcohol binge drinking.

Authors: John C Crabbe; R Adron Harris; George F Koob
Journal: Ann N Y Acad Sci Date: 2011-01 Impact factor: 5.691

Review 3. Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype.

Authors: Matthew M Ford
Journal: Alcohol Date: 2014-02-28 Impact factor: 2.405

4. Lithium effects on adjunctive alcohol consumption in rats.

Authors: G Hines; D F Henslee
Journal: Psychopharmacology (Berl) Date: 1986 Impact factor: 4.530

5. Voluntary Binge Consumption of Ethanol in a Sweetened, Chocolate-Flavored Solution by Male and Female Adolescent Sprague Dawley Rats.

Authors: Dominika Hosová; Linda Patia Spear
Journal: Alcohol Clin Exp Res Date: 2017-02-14 Impact factor: 3.455

10. The effects of ethanol and lead, alone and in combination, on the severity of arrhythmias induced by coronary artery occlusion, and by noradrenaline, in anaesthetised rats.

Authors: M J Evis; K A Kane; M R Moore; J R Parratt
Journal: Arch Toxicol Date: 1986-05 Impact factor: 5.153

Behavioral maintenance of high concentrations of blood ethanol and physical dependence in the rat.

1. Potentiation of ethanol withdrawal by prior dependence.

Review 2. Preclinical studies of alcohol binge drinking.

Review 3. Applications of schedule-induced polydipsia in rodents for the study of an excessive ethanol intake phenotype.

4. Lithium effects on adjunctive alcohol consumption in rats.

5. Voluntary Binge Consumption of Ethanol in a Sweetened, Chocolate-Flavored Solution by Male and Female Adolescent Sprague Dawley Rats.

6. Animal models of excessive alcohol consumption: recent advances and future challenges.

7. Characteristics of ethanol drinking patterns under schedule-induced polydipsia.

Review 8. Advancing addiction treatment: what can we learn from animal studies?

9. Effects of chlordiazepoxide on schedule-induced water and alcohol consumption in the squirrel monkey.

10. The effects of ethanol and lead, alone and in combination, on the severity of arrhythmias induced by coronary artery occlusion, and by noradrenaline, in anaesthetised rats.