Literature DB >> 5059564

Digitonin effects on photoreceptor adenylate cyclase.

M W Bitensky, R E Gorman, W H Miller.   

Abstract

Adenylate cyclase is described in a number of photoreceptor membranes. Vertebrate rod outer segments contain light-regulated cyclase, and light regulation is abolished by digitonin. Disruption of microvilli in cone and rhabdomphotoreceptors is also associated with loss of light regulation and retention of full enzymic activity. The data suggest that inhibitory constraint provides regulation in cyclase systems and that disruption of membrane structure uncouples catalytic and regulatory elements.

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Year:  1972        PMID： 5059564     DOI： 10.1126/science.175.4028.1363

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  The discovery of signal transduction by G proteins: a personal account and an overview of the initial findings and contributions that led to our present understanding.

Authors:  Lutz Birnbaumer
Journal:  Biochim Biophys Acta       Date:  2006-10-04

2.  A temperature-sensitive change in the energy of activation of hormone-stimulated hepatic adenylyl cyclase.

Authors:  P W Kreiner; J J Keirns; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  1973-06       Impact factor: 11.205

Review 3.  Leukocytic proteases and the immunologic release of lysosomal enzymes.

Authors:  G Weissmann; R B Zurier; S Hoffstein
Journal:  Am J Pathol       Date:  1972-09       Impact factor: 4.307

4.  Regulation of cyclic nucleotide concentrations in photoreceptors: an ATP-dependent stimulation of cyclic nucleotide phosphodiesterase by light.

Authors:  N Miki; J J Keirns; F R Marcus; J Freeman; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

5.  Biochemical characterization and cytochemical localization of a catecholamine-sensitive adenylate cyclase in isolated capillary endothelium.

Authors:  R C Wagner; P Kreiner; R J Barrnett; M W Bitensky
Journal:  Proc Natl Acad Sci U S A       Date:  1972-11       Impact factor: 11.205

6.  3',5'-cyclic adenosine monophosphate and adenylate cyclase in phototransduction by limulus ventral photoreceptors.

Authors:  J E Brown; U B Kaupp; C C Malbon
Journal:  J Physiol       Date:  1984-08       Impact factor: 5.182
  6 in total

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