Literature DB >> 5057818

Ultrastructural evidence for nephropathy induced by long-term exposure tosmall amounts of methyl mercury.

B A Fowler.   

Abstract

A low dose of methyl mercuric chloride fed to female rats for 12 weeks caused extrusion of numerous cytoplasmic masses from kidney proximal tubule cells of the pars recta segment. These masses were characterized ultrastructurally by the presence of a smooth endoplasmic reticulum aggregate. The in vivo metabolism of methyl mercury to inorganic mercury may produce this effect and account for the proteinuria observed in persons occupationally exposed to organic mercury compounds.

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Year:  1972        PMID： 5057818     DOI： 10.1126/science.175.4023.780

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Ultrastructural changes in the kidney following chronic exposure to low levels of halothane.

Authors:  L W Chang; A W Dudley; Y K Lee; J Katz
Journal:  Am J Pathol       Date:  1975-02       Impact factor: 4.307

2.  Selective quantification of inorganic mercury in tissues of methylmercury-treated rats.

Authors:  A Yasutake; K Hirayama
Journal:  Bull Environ Contam Toxicol       Date:  1990-11       Impact factor: 2.151

3.  Ultrastructural alterations produced in cockerels after mercuric chloride toxicity and subsequent interaction with an organophosphate insecticide.

Authors:  M A Chishti; T Rotkiewicz
Journal:  Arch Environ Contam Toxicol       Date:  1992-05       Impact factor: 2.804

4.  Sex differential of methylmercury toxicity in spontaneously hypertensive rats (SHR).

Authors:  H Tamashiro; M Arakaki; H Akagi; K Hirayama; K Murao; M H Smolensky
Journal:  Bull Environ Contam Toxicol       Date:  1986-12       Impact factor: 2.151

5.  Mercury and Mink. II. Experimental methyl mercury intoxication.

Authors:  G Wobeser; N O Nielsen; B Schiefer
Journal:  Can J Comp Med       Date:  1976-01

6.  The excretory system of young chickens experiencing mercury toxicity--effects on kidney development, morphology, and function.

Authors:  P Y Hester; J Brake; C V Sikes; P Thaxton; S L Pardue
Journal:  Arch Environ Contam Toxicol       Date:  1978       Impact factor: 2.804

7.  Primate paneth cell degeneration following methylmercury hydroxide ingestion.

Authors:  N K Mottet; R L Body
Journal:  Am J Pathol       Date:  1976-07       Impact factor: 4.307

8.  Blood mercury concentration among residents of a historic mercury mine and possible effects on renal function: a cross-sectional study in southwestern China.

Authors:  Yonghua Li; Biao Zhang; Linsheng Yang; Hairong Li
Journal:  Environ Monit Assess       Date:  2012-07-12       Impact factor: 2.513

9.  The morphologic effects of dieldrin and methyl mercuric chloride on pars recta segments of rat kidney proximal tubules.

Authors:  B A Fowler
Journal:  Am J Pathol       Date:  1972-10       Impact factor: 4.307

Review 10.  Mechanisms of kidney cell injury from metals.

Authors:  B A Fowler
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031
  10 in total

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