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Literature DB >> 5054144

Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal.

Abstract

Preparations of secretory iminunoglobuilin A (S-IgA) isolated from human parotid fluid specifically inhibited the adherence of Streptococcus strains to epithelial cells. Since bacterial adherence is a prerequisite for colonization of mucous surfaces. S-IgA-mediated inhibition of adherence would limit bacterial colonization. This mechanism can explain how secretory immunoglobulins function in the disposal of bacterial antigens.

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Year: 1972 PMID： 5054144 DOI： 10.1126/science.177.4050.697

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

171 in total

1. The role of immune pig colostrum, serum and immunoglobulins IgG, IgM, and IgA, in local intestinal immunity against enterotoxic strain in Escherichia coli O55 in germfree piglets.

Authors: I Miller; J Cerná; J Trávnícek; J Rejnek; J Kruml
Journal: Folia Microbiol (Praha) Date: 1975 Impact factor: 2.099

2. The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.

Authors: F H Green; H Fox
Journal: Gut Date: 1975-02 Impact factor: 23.059

3. Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit.

Authors: A Rudin; G C Riise; J Holmgren
Journal: Infect Immun Date: 1999-06 Impact factor: 3.441

4. Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins.

Authors: R C Williams; R J Gibbons
Journal: Infect Immun Date: 1975-04 Impact factor: 3.441

10. Analysis of immunoglobulin A antibodies to Helicobacter pylori in serum and gastric juice in relation to mucosal inflammation.

Authors: S Hayashi; T Sugiyama; K Yokota; H Isogai; E Isogai; K Oguma; M Asaka; N Fujii; Y Hirai
Journal: Clin Diagn Lab Immunol Date: 1998-09

Inhibition of bacterial adherence by secretory immunoglobulin A: a mechanism of antigen disposal.

1. The role of immune pig colostrum, serum and immunoglobulins IgG, IgM, and IgA, in local intestinal immunity against enterotoxic strain in Escherichia coli O55 in germfree piglets.

2. The distribution of mucosal antibodies in the bowel of patients with Crohn's disease.

3. Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit.

4. Inhibition of streptococcal attachment to receptors on human buccal epithelial cells by antigenically similar salivary glycoproteins.

Review 5. Secretory IgA: arresting microbial pathogens at epithelial borders.

6. Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli type 1 fimbrial lectin.

7. Reaction of human colostral and early milk antibodies with oral streptococci.

8. Agglutination of Streptococcus mutans by low-molecular-weight salivary components: effect of beta 2-microglobulin.

9. Selective binding of blood group-reactive salivary mucins by Streptococcus mutans and other oral organisms.

10. Analysis of immunoglobulin A antibodies to Helicobacter pylori in serum and gastric juice in relation to mucosal inflammation.