Literature DB >> 5052736

Curative potencies against -amanitin poisoning by cytochrome c.

G L Floersheim.   

Abstract

The fatalities occurring after ingestion of the poisonous mushroom Amanita phalloides are thought to be due to alpha-amanitin. Cytochrome c provided antidotal effects against a lethal dose of this toxin in mice. Significant survival was obtained even when the treatment was withheld for 8 hours. The enzyme was superior to a previously explored therapeutic regimen consisting of penicillin and its combination with chloramphenicol and sulfamethoxazole.

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Year:  1972        PMID： 5052736     DOI： 10.1126/science.177.4051.808

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  5 in total

1.  Antagonistic effects against single lethal doses of Amanita phalloides.

Authors:  G L Floersheim
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-05       Impact factor: 3.000

2.  Rifampicin and cysteamine protect against the mushroom toxin phalloidin.

Authors:  G L Floersheim
Journal:  Experientia       Date:  1974-11-15

Review 3.  Treatment of human amatoxin mushroom poisoning. Myths and advances in therapy.

Authors:  G L Floersheim
Journal:  Med Toxicol       Date:  1987 Jan-Feb

Review 4.  Mechanism and treatment of α-amanitin poisoning.

Authors:  Jinfang Xue; Xiran Lou; Deyuan Ning; Ruifei Shao; Guobing Chen
Journal:  Arch Toxicol       Date:  2022-10-21       Impact factor: 6.168

5.  Diagnosis and treatment of Amanita phalloides-type mushroom poisoning: use of thioctic acid.

Authors:  C E Becker; T G Tong; U Boerner; R L Roe; A T ScoTT; M B MacQuarrie; F Bartter
Journal:  West J Med       Date:  1976-08
  5 in total

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