Literature DB >> 505013

Pyruvate dehydrogenase activation in adipocyte mitochondria by an insulin-generated mediator from muscle.

L Jarett, J R Seals.   

Abstract

Material in a chromatographic fraction from an extract of insulin-treated muscle stimulated pyruvate dehydrogenase activity in addipocyte mitochondria. This action was similar to insulin's activation of the enzyme in a plasma membrane-mitochondria mixture. Neither the chromatographic fraction nor insulin required adenosine triphosphate or magnesium ion (Mg2+), suggesting that both agents acted through a calcium-sensitive phosphatase. This fraction may contain a chemical mediator of insulin action.

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Year:  1979        PMID： 505013     DOI： 10.1126/science.505013

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  28 in total

Review 1.  Mechanisms of receptor-mediated transmembrane signalling.

Authors:  M D Hollenberg
Journal:  Experientia       Date:  1986-07-15

2.  Differential sensitivity of two functions of the insulin receptor to the associated proteolysis: kinase action and hormone binding.

Authors:  S Kathuria; S Hartman; C Grunfeld; J Ramachandran; Y Fujita-Yamaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

3.  Inositol, glycogen, insulin, and six nobelists.

Authors:  Joseph Larner
Journal:  J Biol Chem       Date:  2013-03-20       Impact factor: 5.157

4.  Receptor-mediated insulin degradation and insulin-stimulated glycogenesis in cultured foetal hepatocytes.

Authors:  C Plas; B Desbuquois
Journal:  Biochem J       Date:  1982-02-15       Impact factor: 3.857

5.  The endogenous cyclic AMP antagonist, cyclic PIP: its ubiquity, hormone-stimulated synthesis and identification as prostaglandylinositol cyclic phosphate.

Authors:  H K Wasner; U Salge; M Gebel
Journal:  Acta Diabetol       Date:  1993       Impact factor: 4.280

6.  Regulation of pyruvate dehydrogenase kinase activity by protein thiol-disulfide exchange.

Authors:  F H Pettit; J Humphreys; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1982-07       Impact factor: 11.205

7.  Purification and partial characterization of a putative mediator of insulin action on cyclic AMP-dependent protein kinase.

Authors:  M P Thompson; J Larner; D L Kilpatrick
Journal:  Mol Cell Biochem       Date:  1984-04       Impact factor: 3.396

8.  Mechanisms of the fasting-induced dissociation of insulin binding from its action in isolated rat hepatocytes.

Authors:  M Trowbridge; A Sussman; L Ferguson; B Draznin; N Neufeld; N Begum; H Tepperman; J Tepperman
Journal:  Mol Cell Biochem       Date:  1984-04       Impact factor: 3.396

9.  Persistence of the effect of insulin on pyruvate dehydrogenase activity in rat white and brown adipose tissue during the preparation and subsequent incubation of mitochondria.

Authors:  R M Denton; J G McCormack; S E Marshall
Journal:  Biochem J       Date:  1984-01-15       Impact factor: 3.857

10.  Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

Authors:  L M Petruzzelli; S Ganguly; C J Smith; M H Cobb; C S Rubin; O M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  1982-11       Impact factor: 11.205
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