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Literature DB >> 5041506

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs.

Abstract

1. Slices of rabbit spleen generate rabbit aorta contracting substance (RCS) and a prostaglandin of the E series when they are vibrated or stirred.2. The release of both substances is increased by arachidonic acid and inhibited by aspirin-like drugs.3. When the spleen effluent containing RCS and prostaglandin E is incubated for a further 3 min, the prostaglandin concentration increases and the RCS concentration declines.4. RCS may therefore be an unstable intermediate in the biosynthesis of prostaglandins.

Entities: Chemical Species

Mesh：

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Year: 1972 PMID： 5041506 PMCID： PMC1666248 DOI： 10.1111/j.1476-5381.1972.tb09574.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

17 in total

1. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

Authors: P J Piper; J R Vane
Journal: Nature Date: 1969-07-05 Impact factor: 49.962

2. The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.

Authors: B N Davies; E W Horton; P G Withrington
Journal: Br J Pharmacol Chemother Date: 1968-01

3. A novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates.

Authors: C Pace-Asciak; L S Wolfe
Journal: Biochemistry Date: 1971-09-28 Impact factor: 3.162

4. Prostaglandins released by the spleen.

Authors: N Gilmore; J R Vane; J H Wyllie
Journal: Nature Date: 1968-06-22 Impact factor: 49.962

5. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

Authors: J R Vane
Journal: Nat New Biol Date: 1971-06-23

6. Indomethacin and aspirin abolish prostaglandin release from the spleen.

Authors: S H Ferreira; S Moncada; J R Vane
Journal: Nat New Biol Date: 1971-06-23

7. Simplified thin-layer chromatography of prostaglanding in biological extracts.

Authors: A L Willis
Journal: Br J Pharmacol Date: 1970-11 Impact factor: 8.739

8. The release of rabbit aorta contracting substance (RCS) from chopped lung and its antagonism by anti-inflammatory drugs.

Authors: M A Palmer; P J Piper; J R Vane
Journal: Br J Pharmacol Date: 1970-11 Impact factor: 8.739

7. The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins.

Authors: R Gryglewski; J R Vane
Journal: Br J Pharmacol Date: 1972-11 Impact factor: 8.739

8. Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit.

Authors: S B Kandasamy
Journal: Experientia Date: 1977-12-15

9. Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid.

Authors: B B Vargaftig; M Chignard
Journal: Agents Actions Date: 1975-05

10. Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.

Authors: M A Palmer; P J Piper; J R Vane
Journal: Br J Pharmacol Date: 1973-10 Impact factor: 8.739

The release of prostaglandins and rabbit aorta contracting substance (RCS) from rabbit spleen and its antagonism by anti-inflammatory drugs.

1. Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs.

2. The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.

3. A novel prostaglandin derivative formed from arachidonic acid by rat stomach homogenates.

4. Prostaglandins released by the spleen.

5. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.

6. Indomethacin and aspirin abolish prostaglandin release from the spleen.

7. Simplified thin-layer chromatography of prostaglanding in biological extracts.

8. The release of rabbit aorta contracting substance (RCS) from chopped lung and its antagonism by anti-inflammatory drugs.

9. The occurrence of prostaglandin E2 in splenic venous blood of the dog following splenic nerve stimulation.

10. Prostaglandins: their disappearance from and release into the circulation.

Review 1. COX in a crystal ball: current status and future promise of prostaglandin research.

2. Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.

3. On the relation between release of prostaglandins and contractility of rabbit splenic capsular strips.

4. Proceedings: Some actions of bradykinin on mouse isolated ileum.

5. Coupling biological detection to liquid chromatography: a new tool in drug discovery.

6. PGE-release, blood flow and transmucosal water movement after mechanical stimulation of the rat jejunal mucosa.

7. The generation from arachidonic acid of rabbit aorta contracting substance (RCS) by a microsomal enzyme preparation which also generates prostaglandins.

8. Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit.

9. Substances that increase the cyclic AMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid.

10. Release of rabbit aorta contracting substance (RCS) and prostaglandins induced by chemical or mechanical stimulation of guinea-pig lungs.