Literature DB >> 5041457

The effect of drugs on stress-induced changes of myocardial glycogen and blood glucose concentration in rats.

S Prabhu, V N Sharma, V Singh.   

Abstract

Rats that were subjected to restraint stress for 18 h were found to have reduced myocardial glycogen and blood sugar levels and showed histological changes in heart and adrenals. The effects of alpha-methyl-p-tyrosine, alpha-methyl-dopa, disulfiram and actinomycin D on these stress-induced changes were examined. Of these drugs, only alpha-methyl-p-tyrosine was able to prevent the fall in myocardial glycogen and blood sugar and none of the drugs prevented the histological changes induced by stress.

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Year:  1972        PMID： 5041457      PMCID： PMC1665983          DOI： 10.1111/j.1476-5381.1972.tb07321.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  8 in total

1.  The effects of alpha-methyl-DOPA and alpha-methyl-metatyrosine on the metabolism of norepinephrine and serotonin in vivo.

Authors:  S M HESS; R H CONNAMACHER; M OZAKI; S UDENFRIEND
Journal:  J Pharmacol Exp Ther       Date:  1961-11       Impact factor: 4.030

2.  Sympathogenic origin and antiadrenergic prevention of stress-induced myocardial lesions.

Authors:  W RAAB; E STARK; W H MACMILLAN; W R GIGEE
Journal:  Am J Cardiol       Date:  1961-08       Impact factor: 2.778

3.  Improved restraint-technique for producing stress and cardiac necrosis in rats.

Authors:  S RENAUD
Journal:  J Appl Physiol       Date:  1959-09       Impact factor: 3.531

4.  A colorimetric micro-method for the determination of glycogen in tissues.

Authors:  A KEMP; A J M K VAN HEIJNINGEN
Journal:  Biochem J       Date:  1954-04       Impact factor: 3.857

5.  Notes on sugar determination.

Authors:  M SMOGYI
Journal:  J Biol Chem       Date:  1952-03       Impact factor: 5.157

6.  Inhibition of dopamine-beta-hydroxylase by disulfiram in vivo.

Authors:  J M Musacchio; M Goldstein; B Anagnoste; G Poch; I J Kopin
Journal:  J Pharmacol Exp Ther       Date:  1966-04       Impact factor: 4.030

7.  Presence of alpha-methyl-DOPA metabolites in heart and brain of guinea pigs treated with alpha-methyl-tyrosine.

Authors:  L Maître
Journal:  Life Sci       Date:  1965-12       Impact factor: 5.037

8.  Effect of chlorpromazine, mecamylamine and guanethidine on the cold stress induced changes in myocardial glycogen and acetylcholine content in rabbits.

Authors:  V N Sharma; N S Parmar
Journal:  Indian J Med Res       Date:  1967-01       Impact factor: 2.375
  8 in total

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