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Literature DB >> 5041455

Antagonism of GABA by picrotoxin in the feline cerebral cortex.

Abstract

Picrotoxin and gamma-aminobutyric acid (GABA) were applied by microiontophoresis to an unselected population of neurones in the feline cerebral cortex. Picrotoxin was shown to antagonize the depressant effects of GABA and in addition appeared free of some of the actions of bicuculline which tend to mask GABA antagonism.

Entities: Chemical

Mesh：

Substances：

Year: 1972 PMID： 5041455 PMCID： PMC1665993 DOI： 10.1111/j.1476-5381.1972.tb07319.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

12 in total

1. The effect of picrotoxin on peripheral inhibition in the crayfish.

Authors: J ROBBINS; W G VAN DER KLOOT
Journal: J Physiol Date: 1958-10-31 Impact factor: 5.182

2. Antagonism between bicuculline and GABA in the cat brain.

Authors: D R Curtis; A W Duggan; D Felix; G A Johnston; H McLennan
Journal: Brain Res Date: 1971-10-08 Impact factor: 3.252

3. The effect of bicuculline on the gamma-aminobutyric acid (GABA) receptors of neurons of Periplaneta americana and Helix aspersa.

Authors: R J Walker; A R Crossman; G N Woodruff; G A Kerkut
Journal: Brain Res Date: 1971-10-08 Impact factor: 3.252

Review 4. Glutamate and gamma-aminobutyric acid in brain.

Authors: K Krnjević
Journal: Nature Date: 1970-10-10 Impact factor: 49.962

5. Evidence that bicuculline can both potentiate and antagonize GABA.

Authors: R G Hill; M A Simmonds; D W Straughan
Journal: Br J Pharmacol Date: 1971-08 Impact factor: 8.739

6. Doubtful value of bicuculline as a specific antagonist of GABA.

Authors: J M Godfraind; K Krnjević; R Pumain
Journal: Nature Date: 1970-11-14 Impact factor: 49.962

7. Iontophoretic studies in Deiters' nucleus of the inhibitory actions of GABA and related amino acids and the interactions of strychnine and picrotoxin.

Authors: G ten Bruggencate; I Engberg
Journal: Brain Res Date: 1971-02-05 Impact factor: 3.252

8. GABA-picrotoxin interaction in the mammalian central nervous system.

Authors: A Galindo
Journal: Brain Res Date: 1969-08 Impact factor: 3.252

9. Evaluation of bicuculline as a GABA antagonist.

Authors: D W Straughan; M J Neal; M A Simmonds; G G Collins; R G Hill
Journal: Nature Date: 1971-10-01 Impact factor: 49.962

10. A study of the action of picrotoxin on the inhibitory neuromuscular junction of the crayfish.

Authors: A Takeuchi; N Takeuchi
Journal: J Physiol Date: 1969-11 Impact factor: 5.182

7 in total

1. Microiontophoretic study of depressant amino acids and the specificity of their antagonists.

Authors: R G Hill; M A Simmonds; D W Straughan
Journal: Br J Pharmacol Date: 1973-03 Impact factor: 8.739

2. Amino acid antagonists and the depression of cuneate neurones by -aminobutyric acid (GABA) and glycine.

Authors: R G Hill; M A Simmonds; D W Straughan
Journal: Br J Pharmacol Date: 1973-03 Impact factor: 8.739

3. Stoichiometry of a pore mutation that abolishes picrotoxin-mediated antagonism of the GABAA receptor.

Authors: Anna Sedelnikova; Brian E Erkkila; Holly Harris; Stanislav O Zakharkin; David S Weiss
Journal: J Physiol Date: 2006-09-21 Impact factor: 5.182

4. A method for comparing the potencies of -aminobutyric acid antagonists on single cortical neurones using micro-iontophoretic techniques.

Authors: R G Hill; M A Simmonds
Journal: Br J Pharmacol Date: 1973-05 Impact factor: 8.739

5. A comparative study of some convulsant substances as gamma-aminobutyric acid antagonists in the feline cerebral cortex.

Authors: R G Hill; M A Simmonds; D W Straughan
Journal: Br J Pharmacol Date: 1973-09 Impact factor: 8.739

6. Depolarizing actions of gamma-aminobutyric acid and related compounds on rat superior cervical ganglia in vitro.

Authors: N G Bowery; D A Brown
Journal: Br J Pharmacol Date: 1974-02 Impact factor: 8.739

7. Evolution of a central neural circuit underlies Drosophila mate preferences.

Authors: Laura F Seeholzer; Max Seppo; David L Stern; Vanessa Ruta
Journal: Nature Date: 2018-07-11 Impact factor: 49.962

7 in total