Literature DB >> 503866

Evidences for the function of DNA polymerase-beta in unscheduled DNA synthesis.

E Wawra, I Dolejs.   

Abstract

The activities of DNA polymerase-alpha and -beta isolated from pig spleen were determined at different temperatures and in the presence of different concentrations of inhibitors. The results were compared with parallel estimations of replicative DNA synthesis and UV-induced repair synthesis in spleen cells. In respect to pCMB and aCTP, polymerase-alpha is more sensitive than polymerase-beta and similarly is replication more sensitive than repair. Repair synthesis and the activity of polymerase-beta decreases at temperatures higher than 40 degrees C whereas both replication and the activity of polymerase-alpha are greatly stimulated at elevated temperatures with optima of 45 degrees C (polymerase-alpha) and 41 degrees C (replication). The results favour the hypothesis that polymerase-beta is involved in repair synthesis.

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Year:  1979        PMID： 503866      PMCID： PMC342336          DOI： 10.1093/nar/7.6.1675

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  30 in total

1.  A DNA polymerase from Ustilago maydis. Evidence of proof-reading by the associated 3' leads to 5' deoxyribonuclease activity.

Authors:  G T Yarranton; G R Banks
Journal:  Eur J Biochem       Date:  1977-08-01

2.  Differential heat sensitivity of mammalian DNA polymerases.

Authors:  D K Dube; G Seal; L A Loeb
Journal:  Biochem Biophys Res Commun       Date:  1976-05-23       Impact factor: 3.575

3.  Variation of DNA polymerases-alpha, -beta. and -gamma during perinatal tissue growth and differentiation.

Authors:  U Hübscher; C C Kuenzle; S Spadari
Journal:  Nucleic Acids Res       Date:  1977-08       Impact factor: 16.971

4.  Biochemical aspects of cardiac muscle differentiation.

Authors:  W C Claycomb
Journal:  Biochem J       Date:  1978-05-01       Impact factor: 3.857

5.  Comparison of DNA replication and repair enzymology using permeabilized baby hamster kidney cells.

Authors:  J J Castellot; M R Miller; D M Lehtomaki; A B Pardee
Journal:  J Biol Chem       Date:  1979-08-10       Impact factor: 5.157

6.  Involvement of deoxyribonucleic acid polymerase beta in nuclear deoxyribonucleic acid synthesis.

Authors:  T R Butt; W M Wood; E L McKay; R L Adams
Journal:  Biochem J       Date:  1978-07-01       Impact factor: 3.857

7.  Comparison of DNA polymerase alpha and delta from bone marrow.

Authors:  J J Byrnes; V L Black
Journal:  Biochemistry       Date:  1978-10-03       Impact factor: 3.162

8.  Purification and properties of DNA polymerase-beta from guinea pig liver.

Authors:  T A Kunkel; J E Tcheng; R R Meyer
Journal:  Biochim Biophys Acta       Date:  1978-09-27

9.  Yeast DNA polymerases: antigenic relationship, use of RNA primer and associated exonuclease activity.

Authors:  E Wintersberger
Journal:  Eur J Biochem       Date:  1978-03

10.  DNA polymerase beta from brain neurons is a repair enzyme.

Authors:  J Waser; U Hübscher; C C Kuenzle; S Spadari
Journal:  Eur J Biochem       Date:  1979-07
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  6 in total

1.  DNA polymerase beta null mouse embryonic fibroblasts harbor a homozygous null mutation in DNA polymerase iota.

Authors:  Robert W Sobol
Journal:  DNA Repair (Amst)       Date:  2006-09-18

2.  Does hydroxyurea inhibit DNA replication in mouse cells by more than one mechanism?

Authors:  E Wawra; E Wintersberger
Journal:  Mol Cell Biol       Date:  1983-03       Impact factor: 4.272

3.  Mouse DNA polymerase beta gene promoter: fine mapping and involvement of Sp1-like mouse transcription factor in its function.

Authors:  M Yamaguchi; Y Hayashi; A Matsukage
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

4.  Application of arabinofuranosyl cytosine in the kinetic analysis and quantitation of DNA repair in human cells after ultraviolet irradiation.

Authors:  R D Snyder; W L Carrier; J D Regan
Journal:  Biophys J       Date:  1981-08       Impact factor: 4.033

5.  Meiosis in Coprinus: characterization and activities of two forms of DNA polymerase during meiotic stages.

Authors:  K Sakaguchi; B C Lu
Journal:  Mol Cell Biol       Date:  1982-07       Impact factor: 4.272

6.  [The action of hyperthermia on DNA repair (author's transl)].

Authors:  P Weniger; E Wawra; I Dolejs
Journal:  Radiat Environ Biophys       Date:  1979-04-30       Impact factor: 1.925
  6 in total

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