Literature DB >> 50381

Determination of antibody avidity at the cellular level by the plaque inhibition technique: effect of valence of the inhibitor.

E A Goidl, G Birnbaum, G W Siskind.   

Abstract

Inhibition of plaque formation by multivalent and univalent ligands was compared as an assay of avidity of antibody produced by PFC. Multivalent ligands are much more effective as inhibitors and their use tends to impart an appearance of lack of heterogeneity and high avidity to the PFC populations being studied. It is thus probably generally advisable to employ univalent ligands in such studies.

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Year:  1975        PMID： 50381     DOI： 10.1016/0022-1759(75)90080-0

Source DB:  PubMed          Journal:  J Immunol Methods        ISSN： 0022-1759            Impact factor:   2.303


  9 in total

1.  Studies on the control of antibody synthesis. XIII. Preferential depeletion of precursors of high affinity antibody-secreting cells by specific immunoadsorbents.

Authors:  M Slankard-Chahinian; G W Siskind
Journal:  Immunology       Date:  1979-09       Impact factor: 7.397

2.  Detection and analysis of recognition and selection in the immune response.

Authors:  C DeLisi
Journal:  Bull Math Biol       Date:  1977       Impact factor: 1.758

3.  Characterization of the immunodeficiency of RIIIS/J mice: immune response to polysaccharide antigens.

Authors:  J R Hiernaux; P J Baker; S J McEvoy; P W Stashak; M B Fauntleroy; E A Goidl
Journal:  Infect Immun       Date:  1990-05       Impact factor: 3.441

4.  Ontogeny of B-lymphocyte function. V. Thymus cell involvement in the functional maturation of B-lymphocytes from fetal mice transferred into adult irradiated hosts.

Authors:  D H Sherr; M R Szewczuk; G W Siskind
Journal:  J Exp Med       Date:  1978-01-01       Impact factor: 14.307

5.  Differences in the mechanism of tolerance to dinitrophenylated bovine gamma globulin when induced in normal adult mice or in reconstituted irradiated mice: dependence of the mechanism of tolerance on the structural organization of the lymphoid system.

Authors:  M R Szewczuk; M Halliday; T W Soybel; D Turner; G W Siskind; M E Weksler
Journal:  J Exp Med       Date:  1977-04-01       Impact factor: 14.307

6.  Generation of T-helper cells in vitro. II. Analysis of supernates derived from T-helper cell cultures.

Authors:  J S McDougal; D S Gordon
Journal:  J Exp Med       Date:  1977-03-01       Impact factor: 14.307

7.  Ontogeny of B-lymphocyte function. III. In vivo and in vitro studies on the ease of tolerance induction in B lymphocytes from fetal, neonatal, and adult mice.

Authors:  M R Szewczuk; G W Siskind
Journal:  J Exp Med       Date:  1977-06-01       Impact factor: 14.307

8.  Ontogeny of B-lymphocyte function. II. Ability of endotoxin to increase the heterogeneity of affinity of the immune response of B lymphocytes from fetal mice.

Authors:  E A Goidl; J Klass; G W Siskind
Journal:  J Exp Med       Date:  1976-06-01       Impact factor: 14.307

9.  Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells.

Authors:  A F Schrater; E A Goidl; G J Thorbecke; G W Siskind
Journal:  J Exp Med       Date:  1979-07-01       Impact factor: 14.307
  9 in total

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