Literature DB >> 5033649

Salicylate: a structure-activity study of its effects on membrane permeability.

H Levitan, J L Barker.   

Abstract

Salicylate atnd benzoate, and their anlalogs, reversibly increase the membrane potetntial and conductance of identified molluscan neurons by increasing potassium conductance and decreasing chloride conductance. The relative potencies of these compounds were closely correlated with their octanol-water partition coefficients and their pK(a) values.

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Year:  1972        PMID： 5033649     DOI： 10.1126/science.176.4042.1423

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  23 in total

1.  Acidic nonsteroid anti-inflammatory drugs accumulating in inflamed tissue.

Authors:  P Graf; M Glatt; K Brune
Journal:  Experientia       Date:  1975-08-15

2.  Analgesic effect of indomethacin shown using the nociceptive flexion reflex in humans.

Authors:  R Guieu; O Blin; J Pouget; G Serratrice
Journal:  Ann Rheum Dis       Date:  1992-03       Impact factor: 19.103

3.  Sodium salicylate facilitates calcium-dependent release of transmitter at mouse neuromuscular junctions.

Authors:  M Nishimura; H Awano; O Yagasaki
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

4.  Inhibition of prostaglandin synthesis in vivo by nonsteroid anti-inflammatory drugs: evidence for the importance of pharmacokinetics.

Authors:  K Brune; P Graf; M Glatt
Journal:  Agents Actions       Date:  1976-02

5.  Food, drug, and cosmetic dyes: biological effects related to lipid solubility.

Authors:  H Levitan
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

6.  Influence of Phenolic Acids on Ion Uptake: IV. Depolarization of Membrane Potentials.

Authors:  A D Glass
Journal:  Plant Physiol       Date:  1974-12       Impact factor: 8.340

7.  Influence of phenolic acids on ion uptake: I. Inhibition of phosphate uptake.

Authors:  A D Glass
Journal:  Plant Physiol       Date:  1973-06       Impact factor: 8.340

8.  The action of salicylate ions on the frog node of Ranvier.

Authors:  D Attwell; C Bergman; C Ojeda
Journal:  J Physiol       Date:  1979-10       Impact factor: 5.182

9.  Anthracene-9-carboxylic acid inhibits an apical membrane chloride conductance in canine tracheal epithelium.

Authors:  M J Welsh
Journal:  J Membr Biol       Date:  1984       Impact factor: 1.843

10.  Preferential uptake of the non steroid anti-inflammatory drug diclofenac into inflamed tissues after a single oral dose in rats.

Authors:  A Schweitzer; N Hasler-Nguyen; J Zijlstra
Journal:  BMC Pharmacol       Date:  2009-03-16
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