Literature DB >> 5033643

Development of sensitivity to tetrodotoxin in beating chick embryo hearts, single cells, and aggregates.

T F McDonald, H G Sachs, R L DeHaan.   

Abstract

The spontaneous activity of intact embryonic heart becomes progressively more sensitive to tetrodotoxin block with increasing age of the embryo. The activity of isolated single heart cells in culture was relatively insensitive, independent of embryo age. Aggregates formed from single cells responded to tetrodotoxin in the same manner as intact hearts; aggregated cells from older hearts were sensitive.

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Year:  1972        PMID： 5033643     DOI： 10.1126/science.176.4040.1248

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  Electrical activity in embryonic heart cell aggregates. Developmental aspects.

Authors:  T F McDonald; H G Sachs
Journal:  Pflugers Arch       Date:  1975       Impact factor: 3.657

Review 2.  Engineered heart tissues and induced pluripotent stem cells: Macro- and microstructures for disease modeling, drug screening, and translational studies.

Authors:  Evangeline Tzatzalos; Oscar J Abilez; Praveen Shukla; Joseph C Wu
Journal:  Adv Drug Deliv Rev       Date:  2015-09-30       Impact factor: 15.470

3.  In vitro differentiation of a fast Na+ conductance in embryonic heart cell aggregates.

Authors:  R D Nathan; R L DeHaan
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

4.  Isolated bovine ventricular myocytes. Characterization of the action potential.

Authors:  G Isenberg; U Klöckner
Journal:  Pflugers Arch       Date:  1982-10       Impact factor: 3.657

5.  Correlation between relaxation and automaticity in embryonic heart cell aggregates.

Authors:  W T Clusin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-01       Impact factor: 11.205

6.  The mechanical activity of chick embryonic myocardial cell aggregates.

Authors:  W T Clusin; W E Hamilton; D V Nelson
Journal:  J Physiol       Date:  1981-11       Impact factor: 5.182

7.  Differences in degree of electrotonic interaction in highly differentiated and reverted cultured heart cell reaggregates.

Authors:  M J McLean; N Sperelakis
Journal:  J Membr Biol       Date:  1980-11-15       Impact factor: 1.843

8.  Differentiation of the fast Na+ channel in embryonic heart cells: interaction of the channel with neurotoxins.

Authors:  J F Renaud; G Romey; A Lombet; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

9.  Normal serum and lipoprotein-deficient serum give different expressions of excitability, corresponding to different stages of differentiation, in chicken cardiac cells in culture.

Authors:  J F Renaud; A M Scanu; T Kazazoglou; A Lombet; G Romey; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1982-12       Impact factor: 11.205

10.  Calcium-containing vacuolated mitochondria during early heart development in chick embryos as demonstrated by cytochemistry and X-ray microanalysis.

Authors:  S Komazaki; T Hiruma
Journal:  Anat Embryol (Berl)       Date:  1994-05
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