Literature DB >> 5033180

Biosynthesis of C4 (fourth component of complement) by hybrids of C4-deficient guinea pig cells and HeLa cells.

H R Colten, R Parkman.   

Abstract

Peritoneal exudate cells from guinea pigs homozygous for a genetic deficiency of the fourth component of complement (C4) were fused in vitro with a cell line of human origin (HeLa). The resulting hybrid cells, derived from cell lines each incapable of C4 synthesis by themselves, synthesized functionally active human C4.

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Year:  1972        PMID： 5033180     DOI： 10.1126/science.176.4038.1029

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  10 in total

1.  Cell-free synthesis of the fourth component of guinea pig complement (C4): identification of a precursor of serum C4 (pro-C4).

Authors:  R E Hall; H R Colten
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205

Review 2.  Use of somatic cell hybrids for analysis of the differentiated state.

Authors:  F M Davis; E A Adelberg
Journal:  Bacteriol Rev       Date:  1973-06

Review 3.  Molecular genetics of the major histocompatibility linked complement genes.

Authors:  H R Colten
Journal:  Springer Semin Immunopathol       Date:  1983

Review 4.  Cytoplasmic modification of nuclear gene expression.

Authors:  J W Shay
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

5.  In vitro synthesis of a regulator of mammalian gene expression.

Authors:  H R Colten
Journal:  Proc Natl Acad Sci U S A       Date:  1972-08       Impact factor: 11.205

6.  Surface antigens of immunoprotective leukaemia x fibroblast hybrid cells which have lost malignant properties in histocompatible mice differ from the malignant parental cells.

Authors:  R Slomski; D R Wang; E P Cohen
Journal:  Immunology       Date:  1984-06       Impact factor: 7.397

7.  Cytogenetic engineering in vivo: restoration of biologic complement activity to C5-deficient mice by intravenous inoculation of hybrid cells.

Authors:  N L Levy; R Synderman; R L Ladda; R Lieberman
Journal:  Proc Natl Acad Sci U S A       Date:  1973-11       Impact factor: 11.205

8.  Discontinuous variability, in the form of a geometric progression, of albumin production in hepatoma and hybrid cells.

Authors:  J A Peterson
Journal:  Proc Natl Acad Sci U S A       Date:  1974-05       Impact factor: 11.205

9.  Lambda-chain production in human lymphoblast-mouse fibroblast hybrids.

Authors:  S H Orkin; P D Buchanan; W J Yount; H Reisner; J W Littlefield
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205

10.  Localized Derepression on the Human Inactive X Chromosone in Mouse-Human Cell Hybrids.

Authors:  B Kahan; R DeMars
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205
  10 in total

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