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Literature DB >> 5032357

Salicylate: action on normal body temperature in rats.

Abstract

Rats receiving intraperitoneal injections of sodium salicylate (30 to 300 milligrams per kilogram of body weight) showed a decline in rectal temperature of up to 5.5 degrees C when placed in a 5 degrees C environment. High dosages of salicylate lowered the rectal temperatures of rats kept in a 23 degrees C environment. The finding that salicylate can lower nonfebrile body temperature suggests that this class of antipyretic agents does affect normal temperature regulation.

Entities: Chemical Species

Mesh：

Substances：
Salicylates
Sodium

Year: 1972 PMID： 5032357 DOI： 10.1126/science.176.4034.532

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

11 in total

1. Is brain prostaglandin synthesis involved in responses to cold?

Authors: W I Cranston; R F Hellon; D Mitchell
Journal: J Physiol Date: 1975-07 Impact factor: 5.182

2. Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide.

Authors: L T Meltzer; K A Serpa; W H Moos
Journal: Psychopharmacology (Berl) Date: 1989 Impact factor: 4.530

3. Effects of sodium acetylsalicylate on thermoregulatory responses of rats to different ambient temperatures.

Authors: M T Lin
Journal: Pflugers Arch Date: 1978-12-28 Impact factor: 3.657

4. The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine. 1974.

Authors: K Brune; K Bucher; D Walz
Journal: Agents Actions Date: 1994-12

10. Central Nervous Activity upon Systemic Salicylate Application in Animals with Kanamycin-Induced Hearing Loss--A Manganese-Enhanced MRI (MEMRI) Study.

Authors: Moritz Gröschel; Romy Götze; Susanne Müller; Arne Ernst; Dietmar Basta
Journal: PLoS One Date: 2016-04-14 Impact factor: 3.240

Salicylate: action on normal body temperature in rats.

1. Is brain prostaglandin synthesis involved in responses to cold?

2. Evaluation in rats of the somnogenic, pyrogenic, and central nervous system depressant effects of muramyl dipeptide.

3. Effects of sodium acetylsalicylate on thermoregulatory responses of rats to different ambient temperatures.

4. The avian microcrystal arthritis II. Central versus peripheral effects of sodium salicylate, acetaminophen and colchicine. 1974.

5. Antagonism by antipyretics of the hyperthermic effect of a prostaglandin precursor, sodium arachidonate, in the cat.

6. Dietary fatty acid composition influences tissue lipid profiles and regulation of body temperature in Japanese quail.

Review 7. Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action.

8. Sodium salicylate: alternate mechanism of central antipyretic action in the rat.

9. Acetaminophen: antipyretic or hypothermic in mice? In either case, PGHS-1b (COX-3) is irrelevant.

10. Central Nervous Activity upon Systemic Salicylate Application in Animals with Kanamycin-Induced Hearing Loss--A Manganese-Enhanced MRI (MEMRI) Study.