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Literature DB >> 5026162

Isolation and characterization of two major urinary metabolites of 1 -tetrahydrocannabinol.

Abstract

Two of the major metabolites which appear in rabbit urine after the administration of Delta(1)-tetrahydrocannabinol have been isolated and their structures have been tentatively established. The available evidence indicates that they are 7-carboxy-Delta(1)-tetrahydrocannabinols with an additional hydroxyl group on the side chain. The substances occur both free and as conjugates.

Entities: Chemical Species

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Year: 1972 PMID： 5026162 DOI： 10.1126/science.176.4033.422

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

8 in total

Review 1. Human cannabinoid pharmacokinetics.

Authors: Marilyn A Huestis
Journal: Chem Biodivers Date: 2007-08 Impact factor: 2.408

2. Delta 6-tetrahydrocannabinol-7-oic acid, a urinary delta 6-THC metabolite: isolation and synthesis.

Authors: R Mechoulam; Z BenZvi; S Agurell; I M Nilsson; J L Nilsson; H Edery; Y Grunfeld
Journal: Experientia Date: 1973-10-15

Review 3. Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials.

Authors: Summer Burstein
Journal: AAPS J Date: 2005-06-29 Impact factor: 4.009

4. Further studies on the antinociceptive effects of delta 6-THC-7-oic acid.

Authors: S A Doyle; S H Burstein; W L Dewey; S P Welch
Journal: Agents Actions Date: 1990-08

5. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.

Authors: Robert B Zurier; Yee-Ping Sun; Kerri L George; Judith A Stebulis; Ronald G Rossetti; Ann Skulas; Erica Judge; Charles N Serhan
Journal: FASEB J Date: 2009-01-05 Impact factor: 5.191

Isolation and characterization of two major urinary metabolites of 1 -tetrahydrocannabinol.

Review 1. Human cannabinoid pharmacokinetics.

2. Delta 6-tetrahydrocannabinol-7-oic acid, a urinary delta 6-THC metabolite: isolation and synthesis.

Review 3. Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials.

4. Further studies on the antinociceptive effects of delta 6-THC-7-oic acid.

5. Ajulemic acid, a synthetic cannabinoid, increases formation of the endogenous proresolving and anti-inflammatory eicosanoid, lipoxin A4.

Review 6. The cannabinoid acids, analogs and endogenous counterparts.

7. [Enzyme immunochemical detection of the use of hashish and confirmation by thin-layer chromatography].

8. In vitro metabolism and metabolic effects of ajulemic acid, a synthetic cannabinoid agonist.