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Literature DB >> 5016362

Coronary vasodilator responses to hypoxia before and after aminophylline.

S Afonso, T J Ansfield, T B Berndt, G G Rowe.

Abstract

1. In previous studies adenosine has been postulated to be the mediator in coronary blood flow regulation and aminophylline was found to inhibit the coronary vasodilator action of adenosine. The present study was performed to determine whether aminophylline inhibits coronary vasodilatation induced by hypoxia.2. Coronary and systemic haemodynamic and metabolic effects of hypoxia were studied in anaesthetized dogs before and after aminophylline. Aminophylline did not influence coronary vasodilatation induced by hypoxia.3. These results are held not to lend support to the hypothesis that adenosine is the metabolite responsible for the regulation of coronary blood flow.

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Year: 1972 PMID： 5016362 PMCID： PMC1331353 DOI： 10.1113/jphysiol.1972.sp009769

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

6 in total

1. Inhibition of cardiovascular metabolic and hemodynamic effects of adenosine by aminophylline.

Authors: S Afonso; G S O'Brien
Journal: Am J Physiol Date: 1970-12

2. Release of adenosine by the normal myocardium in dogs and its relationship to the regulation of coronary resistance.

Authors: R Rubio; R M Berne
Journal: Circ Res Date: 1969-10 Impact factor: 17.367

3. Release of adenosine in reactive hyperemia of the dog heart.

Authors: R Rubio; R M Berne; M Katori
Journal: Am J Physiol Date: 1969-01

4. Coronary vasodilator responses to hypoxia and induced tachycardia before and after lidoflazine.

Authors: S Afonso
Journal: Am J Physiol Date: 1969-02

5. Inhibition of coronary vasodilating action of dipyridamole and adenosine by aminophylline in the dog.

Authors: S Afonso
Journal: Circ Res Date: 1970-06 Impact factor: 17.367

6. A thermodilution flowmeter.

Authors: S Afonso
Journal: J Appl Physiol Date: 1966-11 Impact factor: 3.531

6 in total

10 in total

5. The acute effects of nicotine, tobacco smoke and carbon monoxide on myocardial oxygen tension in the anaesthetized cat.

Authors: R D Rink
Journal: Br J Pharmacol Date: 1978-04 Impact factor: 8.739

6. Indomethacin and the prostaglandin hypothesis of coronary blood flow regulation.

Authors: S Afonso; G T Bandow; G G Rowe
Journal: J Physiol Date: 1974-09 Impact factor: 5.182

7. Oxygen and coronary vascular resistance during autoregulation and metabolic vasodilation in the dog.

Authors: A J Drake-Holland; J D Laird; M I Noble; J A Spaan; I Vergroesen
Journal: J Physiol Date: 1984-03 Impact factor: 5.182

8. Appearance of adenosine triphosphate in the coronary sinus effluent from isolated working rat heart in response to hypoxia.

Authors: M G Clemens; T Forrester
Journal: J Physiol Date: 1981-03 Impact factor: 5.182

9. Effect of adenosine on the relaxation of coronary arteries at varying pH values.

Authors: S J Mustafa; G Ghai
Journal: Basic Res Cardiol Date: 1981 Jul-Aug Impact factor: 17.165

10. Release of adenosine triphosphate from isolated adult heart cells in response to hypoxia.

Authors: T Forrester; C A Williams
Journal: J Physiol Date: 1977-06 Impact factor: 5.182