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Literature DB >> 5015036

Action of L- -methyldopa-hydrazine on the blood pressure of patients receiving levodopa.

D B Calne, A Petrie, S Rao, J L Reid, S D Vakil.

Abstract

The blood pressure and pulse rate have been compared in a 'double blind, cross over' study involving twenty patients with idiopathic Parkinsonism receiving maximum tolerated dosage of levodopa with and without an extracerebral decarboxylase inhibitor, L-alpha-methyldopahydrazine. The supine and erect systolic pressures were significantly higher and the erect pulse rate significantly lower during administration of L-alpha-methyldopahydrazine. The implications of these observations are discussed.

Entities: Chemical Disease Species

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Year: 1972 PMID： 5015036 PMCID： PMC1665682 DOI： 10.1111/j.1476-5381.1972.tb07249.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

13 in total

1. Central hypotensive effect of L-3,4-dihydroxyphenylalanine in the rat.

Authors: M Henning; A Rubenson
Journal: J Pharm Pharmacol Date: 1970-08 Impact factor: 3.765

2. Effects of L-dopa in Parkinson's disease.

Authors: R B Godwin-Austen; E B Tomlinson; C C Frears; H W Kok
Journal: Lancet Date: 1969-07-26 Impact factor: 79.321

3. Effect of L-dopa alone and in combination with an extracerebral decarboxylase inhibitor on blood pressure and some cardiovascular reflexes.

Authors: A M Watanabe; T N Chase; P V Cardon
Journal: Clin Pharmacol Ther Date: 1970 Sep-Oct Impact factor: 6.875

4. Treatment of parkinsonism with levodopa.

Authors: M D Yahr; R C Duvoisin; M J Schear; R E Barrett; M M Hoehn
Journal: Arch Neurol Date: 1969-10

5. Anesthesia and the responsiveness of individual neurons of the caudate nucleus of the cat to acetylcholine, norepinephrine and dopamine administered by microelectrophoresis.

Authors: F E Bloom; E Costa; G C Salmoiraghi
Journal: J Pharmacol Exp Ther Date: 1965-11 Impact factor: 4.030

6. Cardiovascular effects of dopamine in the anesthetized cat.

Authors: G Ross; A W Brown
Journal: Am J Physiol Date: 1967-04

7. Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow.

Authors: J L McNay; L I Goldberg
Journal: J Pharmacol Exp Ther Date: 1966-01 Impact factor: 4.030

8. The metabolism of orally administered L-Dopa in Parkinsonism.

Authors: D B Calne; F Karoum; C R Ruthven; M Sandler
Journal: Br J Pharmacol Date: 1969-09 Impact factor: 8.739

9. Idiopathic Parkinsonism treated with an extracerebral decarboxylase inhibitor in combination with levodopa.

Authors: D B Calne; J L Reid; S D Vakil; S Rao; A Petrie; C A Pallis; J Gawler; P K Thomas; A Hilson
Journal: Br Med J Date: 1971-09-25

10. Hypotension caused by L-dopa.

Authors: D B Calne; J Brennan; A S Spiers; G M Stern
Journal: Br Med J Date: 1970-02-21

6 in total

Review 1. Augmenting the action of levodopa.

Authors: S K Rao; S D Vakil; D B Calne; A Hilson
Journal: Postgrad Med J Date: 1972-11 Impact factor: 2.401

Review 2. Levodopa and decarboxylase inhibitors: a review of their clinical pharmacology and use in the treatment of parkinsonism.

Authors: R M Pinder; R N Brogden; P R Sawyer; T M Speight; G S Avery
Journal: Drugs Date: 1976 Impact factor: 9.546

Review 3. Anti-parkinsonian drugs today.

Authors: N P Quinn
Journal: Drugs Date: 1984-09 Impact factor: 9.546