Literature DB >> 5013681

Griseofulvin: a teratogenic study.

M F Klein, J R Beall.   

Abstract

Griseofulvin, a fungistatic agent, was administered in oral doses of 125 to 1500 milligrams per kilogramn per day to pregnant rats during organogenesis. Evaluation of the offspring from dams treated with the largest doses, 63 and 75 times a therapeutic dose in man, indicated decreased survival rates and a syndrome of malformations.

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Year:  1972        PMID： 5013681     DOI： 10.1126/science.175.4029.1483

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  Use and safety of antimicrobial agents during pregnancy.

Authors:  A W Chow; P J Jewesson
Journal:  West J Med       Date:  1987-06

Review 2.  Infectious diseases: annual review of significant publications.

Authors:  H A Reimann
Journal:  Postgrad Med J       Date:  1973-05       Impact factor: 2.401

3.  Griseofulvin, a possible teratogen.

Authors:  A Gillick; W S Bulmer
Journal:  Can Vet J       Date:  1972-10       Impact factor: 1.008

4.  Kinetic suppression of microtubule dynamic instability by griseofulvin: implications for its possible use in the treatment of cancer.

Authors:  Dulal Panda; K Rathinasamy; Manas K Santra; Leslie Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-06-28       Impact factor: 11.205

5.  Chemical induction of sperm abnormalities in mice.

Authors:  A J Wyrobek; W R Bruce
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

6.  Chemical-biological reactions common to teratogenesis and mutagenesis.

Authors:  R D Harbison
Journal:  Environ Health Perspect       Date:  1978-06       Impact factor: 9.031

7.  Thyroid tumours in rats and hepatomas in mice after griseofulvin treatment.

Authors:  M Rustia; P Shubik
Journal:  Br J Cancer       Date:  1978-08       Impact factor: 7.640
  7 in total

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