| Literature DB >> 5008609 |
Abstract
Water-deprived rats were administered a single dose of Delta(9)-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.Entities:
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Year: 1972 PMID： 5008609 DOI： 10.1126/science.175.4024.911
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728