Literature DB >> 500835

A new chromogenic assay for the specific determination of prothrombin.

J L Francis.   

Abstract

A new method for the specific assay of prothrombin is described which utilises Taipan snake venom and the chromogenic substrate Tos-Gly-Pro-Arg-pNA (Chromozym TH). The method is sensitive and reproducible and shows good correlation with a conventional specific assay for prothrombin. The reaction is dependent on calcium ions and phospholipid, and is therefore sensitive to the coumarin-induced prothrombin defect. The assay is rapid and well suited for use in the routine coagulation laboratory.

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Year:  1979        PMID： 500835      PMCID： PMC1145770          DOI： 10.1136/jcp.32.7.651

Source DB:  PubMed          Journal:  J Clin Pathol        ISSN： 0021-9746            Impact factor:   3.411


  10 in total

1.  A new era in the laboratory evaluation of coagulation and fibrinolysis.

Authors:  H Stormorken
Journal:  Thromb Haemost       Date:  1976-11-30       Impact factor: 5.249

2.  The measurement of prothrombin in plasma; a case of prothrombin deficiency.

Authors:  R BIGGS; A S DOUGLAS
Journal:  J Clin Pathol       Date:  1953-02       Impact factor: 3.411

3.  Detection and measurement of low levels of prothrombin. Use of a procoagulant from Echis carinatus venom.

Authors:  B R Franza; D L Aronson
Journal:  Thromb Res       Date:  1976-03       Impact factor: 3.944

4.  Determination of plasma prothrombin with a reaction rate analyzer using a synthetic substrate.

Authors:  K Bergström; M Blombäck
Journal:  Thromb Res       Date:  1974-06       Impact factor: 3.944

5.  Specific assay of prothrombin. A method using a freeze-dried reagent of intrinsic coagulation factors.

Authors:  I Norén
Journal:  Scand J Clin Lab Invest       Date:  1970-01       Impact factor: 1.713

6.  Coagulant and anticoagulant action of snake venoms.

Authors:  K W Denson
Journal:  Toxicon       Date:  1969-06       Impact factor: 3.033

7.  The specific Assay of prothrombin using the Taipan snake venom.

Authors:  K W Denson; R Borrett; R Biggs
Journal:  Br J Haematol       Date:  1971-08       Impact factor: 6.998

8.  Determination of vitamin K sensitive coagulation factors in plasma: studies on three methods using synthetic chromogenic substrates.

Authors:  K Bergström; N Egberg
Journal:  Thromb Res       Date:  1978-03       Impact factor: 3.944

9.  Activation of human prothrombin by a procoagulant fraction from the venom of Echis carinatus. Identification of a high molecular weight intermediate with thrombin activity.

Authors:  B R Franza; D L Aronson; J S Finlayson
Journal:  J Biol Chem       Date:  1975-09-10       Impact factor: 5.157

10.  Studies on assays for plasma prekallikrein and for the monitoring of coumarol therapy.

Authors:  N Egberg; K Bergström
Journal:  Haemostasis       Date:  1978
  10 in total

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