Literature DB >> 5002818

Production of albumin and other serum proteins by clonal cultures of normal human liver.

M E Kaighn, A M Prince.   

Abstract

Clonal cell strains have been isolated from normal human liver. These cells, while resembling fibroblasts morphologically, function as hepatocytes, as shown by their ability to synthesize and secrete an antigen identical to human serum albumin. Human diploid and aneuploid cell lines from nonliver sources do not exhibit this property. The spectrum of serum proteins synthesized varied from clone to clone and cell line to cell line.

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Year:  1971        PMID： 5002818      PMCID： PMC389430          DOI： 10.1073/pnas.68.10.2396

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  24 in total

1.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

2.  Clonal analysis of myogenesis.

Authors:  I R KONIGSBERG
Journal:  Science       Date:  1963-06-21       Impact factor: 47.728

3.  The cultivation of human embryonic liver cells.

Authors:  W D HILLIS; F B BANG
Journal:  Exp Cell Res       Date:  1962-02       Impact factor: 3.905

4.  Production of serum albumin and of globulins by chick mesenchymal tissue and by HeLa tumour tissue in culture.

Authors:  Y ABDEL-SAMIE; E BRODA; G KELLNER; W ZISCHKA
Journal:  Nature       Date:  1959-08-01       Impact factor: 49.962

5.  Human cells in continuous culture. I. Derivation of cell strains from esophagus, palate, liver, and lung.

Authors:  J T SYVERTON; L C McLAREN
Journal:  Cancer Res       Date:  1957-10       Impact factor: 12.701

6.  TISSUE CULTURE POPULATIONS AND THEIR RELATION TO THE TISSUE OF ORIGIN.

Authors:  G Sato; L Zaroff; S E Mills
Journal:  Proc Natl Acad Sci U S A       Date:  1960-07       Impact factor: 11.205

7.  Rates of albumin and transferrin synthesis in vitro in rat hepatoma-derived H4II-EC cells.

Authors:  S H Ohanian; S B Taubman; G J Thorbecke
Journal:  J Natl Cancer Inst       Date:  1969-08       Impact factor: 13.506

8.  Synthesis of the ninth component of complement by a clonal strain of rat hepatoma cells.

Authors:  F A Rommel; M B Goldlust; F C Bancroft; M M Mayer; A H Tashjian
Journal:  J Immunol       Date:  1970-08       Impact factor: 5.422

9.  Immunochemical quantitation of antigens by single radial immunodiffusion.

Authors:  G Mancini; A O Carbonara; J F Heremans
Journal:  Immunochemistry       Date:  1965-09

10.  Establishment of a clonal strain of hepatoma cells which secrete albumin.

Authors:  U I Richardson; A H Tashjian; L Levine
Journal:  J Cell Biol       Date:  1969-01       Impact factor: 10.539
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  34 in total

1.  Albumin, fibrinogen and transferrin synthesis in isolated rat hepatocyte suspensions. A model for the study of plasma protein synthesis.

Authors:  K N Jeejeebhoy; J Ho; G R Greenberg; M J Phillips; A Bruce-Robertson; U Sodtke
Journal:  Biochem J       Date:  1975-01       Impact factor: 3.857

2.  Wilms' tumor cell line.

Authors:  W A Nelson-Rees
Journal:  In Vitro       Date:  1979-10

3.  The establishment and continuous subculturing of normal human adult hepatocytes: expression of differentiated liver functions.

Authors:  R E Gibson-D'Ambrosio; D L Crowe; C E Shuler; S M D'Ambrosio
Journal:  Cell Biol Toxicol       Date:  1993 Oct-Dec       Impact factor: 6.691

4.  Conditions affecting primary cell cultures of functional adult rat hepatocytes. 1. The effect of insulin.

Authors:  B A Laishes; G M Williams
Journal:  In Vitro       Date:  1976-07

5.  Cell lines from non-neoplastic liver and hepatocellular carcinoma tissue from a single patient.

Authors:  M Noguchi; S Hirohashi
Journal:  In Vitro Cell Dev Biol Anim       Date:  1996-03       Impact factor: 2.416

6.  Studies with mature rat hepatocytes in monolayer culture. I. Propagation of isolated hepatocytes, morphological and biochemical in culture.

Authors:  S Odashima; J M Sturgess; A Rothstein
Journal:  Cell Tissue Res       Date:  1976-06-14       Impact factor: 5.249

7.  Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.

Authors:  A M Pfeifer; K E Cole; D T Smoot; A Weston; J D Groopman; P G Shields; J M Vignaud; M Juillerat; M M Lipsky; B F Trump
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-01       Impact factor: 11.205

8.  Premalignancy in vitro: progression of an initially benign epithelial cell line to malignancy.

Authors:  L W Anderson; H S Smith
Journal:  Br J Exp Pathol       Date:  1979-12

9.  A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis.

Authors:  R A Stockley; M Mistry; A R Bradwell; D Burnett
Journal:  Thorax       Date:  1979-12       Impact factor: 9.139

10.  Change in alpha 1-antitrypsin phenotype after orthotopic liver transplant.

Authors:  R van Furth; J A Kramps; A B van der Putten; R A Krom; C H Gips
Journal:  Clin Exp Immunol       Date:  1986-12       Impact factor: 4.330
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